Barbaro Francesca, Canton Luciano, Uzunov Nikolay, De Nardo Laura, Meléndez-Alafort Laura
University of Padova, Dept of Physics and Astronomy, Via Marzolo 8, Padova, Italy; INFN, Padova unit, Via Marzolo 8, Padova, Italy.
INFN, Padova unit, Via Marzolo 8, Padova, Italy.
Appl Radiat Isot. 2025 Nov;225:112026. doi: 10.1016/j.apradiso.2025.112026. Epub 2025 Jul 17.
Terbium radionuclides are gaining prominence in theranostics, with Tb emerging as promising SPECT imaging agent due to its γ emissions (87 keV, 32%; 105 keV, 25%) and favorable half-life (T=5.32 days), allowing extended biodistribution monitoring. However, efficient production via hospital cyclotrons is challenging, particularly in reducing Tb contamination, which affects image quality and increases patient dose. This study investigates the Gd(p,n)Tb reaction, highlighting the importance of Gd target enrichment.
铽放射性核素在诊疗一体化中日益受到关注，由于铽的γ发射（87 keV，32%；105 keV，25%）和良好的半衰期（T = 5.32天），使其成为一种有前景的单光子发射计算机断层扫描（SPECT）成像剂，能够进行长时间的生物分布监测。然而，通过医院回旋加速器进行高效生产具有挑战性，特别是在减少铽污染方面，铽污染会影响图像质量并增加患者剂量。本研究调查了钆（Gd，镧系元素）（p，n）铽反应，强调了钆靶富集的重要性。
