Wang Mingzhu, Xia Nan, Wu Qiongfang, Jiang Tingting, Peng Chengchao, Li Jinghong, Li Danping, Lou Wei Wei, Lu Min
Department of Rehabilitation Medicine, Huazhong University of Science and Technology Tongji Medical College Tongji Hospital, Wuhan, Hubei, China.
Department of Critical Care Medicine, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
BMJ Open. 2025 Jul 28;15(7):e086791. doi: 10.1136/bmjopen-2024-086791.
Dysarthria is one of the most prevalent communication disorders following a stroke, and it can lead to social isolation and depression, significantly hindering rehabilitation progress. Recent studies suggest that acoustic startle priming (ASP) tasks may enhance speech performance and motor initiation through the corticoreticulospinal tract. This has opened up new possibilities for the application of ASP in the rehabilitation of poststroke dysarthria. The aim of this study is to investigate whether ASP can improve rehabilitation outcomes in individuals with poststroke dysarthria.
This prospective, randomised, controlled clinical trial plans to enrol 48 participants diagnosed with poststroke dysarthria. Participants will be randomly assigned to either the ASP group (n=24) or the control group (n=24). Both groups will undergo 30 min of standard dysarthria rehabilitation training daily, 5 days per week for 2 weeks. The ASP group will receive an additional 30 min articulation training with ASP, while the control group will receive an equivalent 30 min articulation training with normal acoustic stimuli. Speech and voice characteristics will be assessed using Frenchay Dysarthria Assessment, PRAAT software at baseline, 1 week and 2 weeks postintervention. Furthermore, Functional Near Infrared Spectroscopy will be employed during ASP tasks to investigate cortical activation and changes in brain network connectivity.
The study has been approved by the Tongji Hospital Medical Ethics Committee (TJ-IRB202312100). Raw data from this trial will be publicly available on the Public Management Platform for Clinical Research. The findings will be disseminated through international conferences and peer-reviewed journals.
ChiCTR2400081279.
构音障碍是中风后最常见的交流障碍之一，它会导致社交孤立和抑郁，严重阻碍康复进程。最近的研究表明，听觉惊吓启动（ASP）任务可能通过皮质网状脊髓束改善言语表现和运动启动。这为ASP在中风后构音障碍康复中的应用开辟了新的可能性。本研究的目的是调查ASP是否能改善中风后构音障碍患者的康复效果。
这项前瞻性、随机、对照临床试验计划招募48名被诊断为中风后构音障碍的参与者。参与者将被随机分配到ASP组（n = 24）或对照组（n = 24）。两组患者每周5天，每天接受30分钟的标准构音障碍康复训练，共2周。ASP组将额外接受30分钟的ASP发音训练，而对照组将接受同等时长的正常听觉刺激发音训练。在基线、干预后1周和2周，使用Frenchay构音障碍评估法、PRAAT软件评估言语和嗓音特征。此外，在ASP任务期间将采用功能近红外光谱技术，以研究皮质激活和脑网络连接的变化。
本研究已获得同济医院医学伦理委员会批准（TJ - IRB202312100）。该试验的原始数据将在临床研究公共管理平台上公开。研究结果将通过国际会议和同行评审期刊进行传播。
ChiCTR2400081279。
