Wu Jiayi, Zhou Li, He Sitong, Tang Xuna, Wang Jue, Li Yanan
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P.R. China.
Department of specialist clinic, Nanjing Stomatological Hospital, Medical School, Nanjing University 210008, P.R. China.
J Microbiol Biotechnol. 2025 Jul 14;35:e2502053. doi: 10.4014/jmb.2502.02053.
Supplementation with appropriate doses of has been reported to potentially attenuate immune changes. While some progress has been made in studying the immune function of LRa05, a lack of systematic summaries has led to the neglect of its application in enhancing immune function. This study aimed to investigate the effects of LRa05 on the immune function of mice and to evaluate its safety profile as a dietary supplement. Mice were divided into three dosage groups (0.205, 0.410, and 1.230 g/kg body weight [BW]) and a negative control group (PBS), with each group orally gavaged for 30 consecutive days. The study assessed body weight, organ-to-body weight ratio, cellular immune function, humoral immune function, monocyte-macrophage phagocytic function and NK cell activity. Additionally, a subsequent 90-day subchronic oral toxicity study was conducted on rats to evaluate the safety of consumption. Significant differences were observed in the number of antibody-producing cells, carbon clearance function, and NK cell activity across all dosage groups compared to the negative control group, indicating that LRa05 has a superior ability to enhance immunity. During the 90-day subchronic oral toxicity experiment, no obvious damage was observed, demonstrating its good safety profile for consumption. This study underscores the immunopotentiating effects of LRa05 and its safety as a dietary supplement, recommending it as a promising candidate for integration into the food and health food industries.
据报道，补充适当剂量的[物质名称未给出]可能会减轻免疫变化。虽然在研究LRa05的免疫功能方面已经取得了一些进展，但缺乏系统的总结导致其在增强免疫功能方面的应用被忽视。本研究旨在探讨LRa05对小鼠免疫功能的影响，并评估其作为膳食补充剂的安全性。将小鼠分为三个剂量组（0.205、0.410和1.230 g/kg体重[BW]）和一个阴性对照组（PBS），每组连续30天经口灌胃。该研究评估了体重、器官与体重比、细胞免疫功能、体液免疫功能、单核细胞-巨噬细胞吞噬功能和NK细胞活性。此外，随后对大鼠进行了为期90天的亚慢性经口毒性研究，以评估[物质名称未给出]食用的安全性。与阴性对照组相比，所有剂量组在抗体产生细胞数量、碳清除功能和NK细胞活性方面均观察到显著差异，表明LRa05具有卓越的增强免疫力的能力。在为期90天的亚慢性经口毒性实验中，未观察到明显损伤，证明其食用安全性良好。本研究强调了LRa05的免疫增强作用及其作为膳食补充剂的安全性，推荐其作为食品和保健食品行业整合的有前途的候选物。
