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使用新型移动磷光体探头系统对伽玛刀放射外科进行三维患者特异性质量保证的可行性测试。

Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system.

作者信息

Lee Minsik, Yoon KyoungJoon, Shin Jun-Bong, Lee BongHyo, Kwak Jungwon, Lee DoHeui

机构信息

Department of Radiation Oncology, Kangwon National University Hospital, 156, Baengnyeong-ro, Chuncheon-si, 24289, Gangwon-do, Korea.

Department of Radiation Oncology, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

出版信息

Sci Rep. 2025 Jul 29;15(1):27615. doi: 10.1038/s41598-025-04925-1.

DOI:10.1038/s41598-025-04925-1
PMID:40730833
Abstract

This study evaluates a novel three-dimensional (3D) quality assurance (QA) device, the Mobile Phosphor Probe (MPP), for pretreatment dose verification in Gamma Knife (GK) stereotactic radiosurgery. The MPP system consists of a cylindrical phantom with a phosphor screen, an imaging unit with a charge-coupled device (CCD) camera, and a motorized driving unit. Dose distributions are reconstructed from images using a lookup table, which correlates CCD pixel optical density with dose values, calibrated against EBT3 film readings. Results show that the full width at half maximum of normalized dose distributions between film and CCD were consistent within a 0.2 mm margin. A 3D dose distribution was constructed by stacking two-dimensional images obtained at 0.3 mm intervals over a ± 30 mm range in the superior-inferior direction. Validation was achieved by comparing the reconstructed 3D doses with planned distributions across multiple planes using gamma evaluation. All cases within the 20-80% isodose line (IDL) range achieved a 95% gamma passing rate under 2.0%/2.0 mm criteria, and the 1.0%/1.0 mm criteria were met at the 50% IDL in all dimensions. The MPP system demonstrates potential as an efficient patient-specific QA tool for GK radiosurgery, offering a streamlined alternative to traditional film dosimetry.

摘要

本研究评估了一种新型三维(3D)质量保证(QA)设备——移动磷光探头(MPP),用于伽玛刀(GK)立体定向放射治疗中的治疗前剂量验证。MPP系统由一个带有磷光屏的圆柱形模体、一个带有电荷耦合器件(CCD)相机的成像单元和一个电动驱动单元组成。使用查找表从图像中重建剂量分布,该查找表将CCD像素光密度与剂量值相关联,并根据EBT3胶片读数进行校准。结果表明,胶片和CCD之间归一化剂量分布的半高宽在0.2毫米的容差范围内是一致的。通过在上下方向±30毫米范围内以0.3毫米间隔堆叠获得的二维图像来构建三维剂量分布。通过使用伽马评估比较重建的三维剂量与多个平面上的计划分布来实现验证。在2.0%/2.0毫米标准下,20-80%等剂量线(IDL)范围内的所有病例均达到95%的伽马通过率,并且在所有维度的50% IDL处均满足1.0%/1.0毫米标准。MPP系统展示了作为GK放射治疗有效的患者特异性QA工具的潜力,为传统胶片剂量测定提供了一种简化的替代方案。

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Feasibility test of 3 dimensional patient specific quality assurance of gamma knife radiosurgery using novel mobile phospor probe system.使用新型移动磷光体探头系统对伽玛刀放射外科进行三维患者特异性质量保证的可行性测试。
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本文引用的文献

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Gel dosimetry has a viable future for dosimetry in the radiation oncology clinic.凝胶剂量测定法在放射肿瘤学临床剂量测定中有着可行的未来。
Phys Eng Sci Med. 2024 Mar;47(1):1-5. doi: 10.1007/s13246-023-01365-x.
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无框架立体定向放射外科中基于伽玛刀 Icon 锥形束 CT 的总流程不确定性。
J Appl Clin Med Phys. 2022 May;23(5):e13564. doi: 10.1002/acm2.13564. Epub 2022 Feb 14.
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Replacing gamma knife beam-profiles on film with point-detector scans.用点探测器扫描取代胶片上的伽玛刀射束轮廓。
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Phys Med Biol. 2018 Oct 18;63(20):20NT03. doi: 10.1088/1361-6560/aae457.
8
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Radiosurgery with the world's first fully robotized Leksell Gamma Knife PerfeXion in clinical use: a 200-patient prospective, randomized, controlled comparison with the Gamma Knife 4C.全球首款投入临床使用的全自动化Leksell伽玛刀PerfeXion进行的放射外科治疗:与伽玛刀4C对200例患者进行的前瞻性、随机、对照比较。
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