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育龄期孕妇与非孕妇COVID-19临床结局的比较。

Comparison of the clinical outcomes of COVID-19 in pregnant and non-pregnant patients of reproductive age.

作者信息

Karzad Nazila, Taghavi Simin, Mahmoodpoor Ata, Saghaleini Seied Hadi, Safiri Saeid, Hosseinzadeh Pouya

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Anesthesiology, School of Medicine, Imam Reza Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Eur J Med Res. 2025 Jul 29;30(1):681. doi: 10.1186/s40001-025-02733-x.

Abstract

PURPOSE

This study aims to compare the clinical course of COVID-19 in pregnant versus non-pregnant women aged 15-45 in Tabriz, focusing on disease severity, mortality, and pregnancy outcomes.

METHODS

A total of 300 women were analyzed, with 150 pregnant and 150 non-pregnant participants. Data collected included demographic information, comorbidities, clinical outcomes, and pregnancy-related complications.

RESULTS

The mean age of pregnant women was 32 years, while non-pregnant women averaged 38 years. Common comorbidities in the pregnant group included gestational diabetes and hypertension. Pregnant women predominantly experienced mild COVID-19 cases, whereas severe cases were more frequent in non-pregnant women; however, these differences were not statistically significant. Both groups had a mortality rate of 4.7%, with seven deaths reported in each cohort. Among pregnant women, 19% experienced preterm births, 6.7% had miscarriages, 3.5% had stillbirths, and 6.7% faced postpartum hemorrhages, with most preterm births being induced.

CONCLUSIONS

The findings suggest that pregnancy does not worsen the clinical course of COVID-19, as pregnant women generally exhibit milder symptoms and require fewer intensive care unit admissions compared to their non-pregnant counterparts.

摘要

目的

本研究旨在比较大不里士地区15至45岁孕妇与非孕妇感染新型冠状病毒肺炎(COVID-19)的临床病程,重点关注疾病严重程度、死亡率和妊娠结局。

方法

共分析了300名女性,其中150名孕妇和150名非孕妇。收集的数据包括人口统计学信息、合并症、临床结局和妊娠相关并发症。

结果

孕妇的平均年龄为32岁,而非孕妇的平均年龄为38岁。孕妇组常见的合并症包括妊娠期糖尿病和高血压。孕妇主要为轻症COVID-19病例,而非孕妇中重症病例更为常见;然而,这些差异无统计学意义。两组的死亡率均为4.7%,每组均报告有7例死亡。在孕妇中,19%发生早产,6.7%流产,3.5%死产,6.7%出现产后出血,大多数早产为引产。

结论

研究结果表明,妊娠不会使COVID-19的临床病程恶化,因为与非孕妇相比,孕妇通常症状较轻,入住重症监护病房的需求较少。

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