Chow W H, Daling J R, Weiss N S, Moore D E, Soderstrom R
Am J Obstet Gynecol. 1985 Dec 1;153(7):727-9. doi: 10.1016/0002-9378(85)90332-1.
The incidence of ectopic pregnancy in the United States has more than doubled in the past decade. Because a previous study has suggested that the practice of vaginal douching may increase the risk of pelvic inflammatory disease, a condition known to predispose to ectopic pregnancy, and because the sale of commercial douching products in the United States has more than tripled since 1974, we investigated this practice as a possible risk factor. We interviewed 155 women who had a tubal ectopic pregnancy treated at five Seattle hospitals between 1975 and 1979 as to their reproductive, contraceptive, and medical histories, demographic characteristics, and personal hygiene practices. During the same period, 456 women who were delivered of a baby in King County were identified from Vital Records and interviewed as controls. A higher proportion of cases than controls reported ever having douched in the past. Cases also douched more frequently than controls. After simultaneous adjusting for confounding factors in our data by means of a multiple logistic regression technique, the risk of tubal ectopic pregnancy for women who douched at least weekly was twice that of women who never douched (95% confidence interval = 1.03 to 4.00). The risk for women who used commercial douches on a weekly basis was 4.4 (95% confidence interval = 1.6 to 12.7) the risk for women who never douched.
在过去十年中，美国宫外孕的发病率增加了一倍多。由于之前的一项研究表明，阴道灌洗可能会增加盆腔炎的风险，而盆腔炎是一种已知的易引发宫外孕的疾病，并且自1974年以来，美国商业灌洗产品的销量增长了两倍多，因此我们将这种行为作为一个可能的风险因素进行了调查。我们采访了1975年至1979年间在西雅图五家医院接受输卵管宫外孕治疗的155名女性，询问了她们的生殖、避孕和病史、人口统计学特征以及个人卫生习惯。在同一时期，从生命记录中识别出456名在金县分娩的女性作为对照并进行了采访。报告过去曾进行过灌洗的病例比例高于对照。病例灌洗的频率也高于对照。通过多元逻辑回归技术对我们数据中的混杂因素进行同时调整后，每周至少进行一次灌洗的女性发生输卵管宫外孕的风险是从未灌洗女性的两倍（95%置信区间=1.03至4.00）。每周使用商业灌洗产品的女性的风险是从未灌洗女性的4.4倍（95%置信区间=1.6至12.7）。
