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第二代和第三代富勒烯C衍生物合成的分子“阴阳”机制。

Molecular "Yin-Yang" Machinery of Synthesis of the Second and Third Fullerene C Derivatives.

作者信息

Koruga Djuro Lj, Matija Lidija R, Stanković Ivana M, Pavlović Vladimir B, Dinić Aleksandra P

机构信息

NanoLab, Biomedical Engineering, Faculty of Mechanical Engineering, University of Belgrade, 11120 Belgrade, Serbia.

TEM Laboratory, Faculty of Agriculture, University of Belgrade, 11000 Belgrade, Serbia.

出版信息

Micromachines (Basel). 2025 Jun 30;16(7):770. doi: 10.3390/mi16070770.

Abstract

To overcome the negative effects of the biochemical application of nano-substances in medicine (toxicity problem), using the example of fullerene C's first derivative (fullerenol, FD-C), we show that their biophysical effect is possible through non-covalent hydrogen bonds when around FD-C water layers are formed. SD-C (Zeta potential is -43.29 mV) is much more stable than fullerol (Zeta potential is -25.85 mV), so agglomeration/fragmentation of the fullerol structure, due to instability, can cause toxic effects. When fullerol in solution was exposed to an oscillatory magnetic field with (real) part [250/-92 mT, H() = (ωt)], water layers around FD-C (fullerenol) are formed according to the Penrose process of 3D tiling formation, and the second derivative, SD-C (or 3HFWC), is self-organized. However, when (imaginary) part [250/-92 mT, H() = (ωt)] of the external magnetic field is applied in addition to SD-C, ordered water chains and bubbling of water ("micelle") are formed as a third derivative (TD-C). Fullerol (FD-C) interacts with biological structures biochemically, while the second (SD-C) and third (TD-C) derivatives act biophysically via non-covalent hydrogen bond oscillation. SD-C and TD-C significantly increased water solubility and reduced toxicity. The paper explains the synthesis of SD-C60 and TD-C60 from FD-C60 (fullerol) as a precursor by the influence of an oscillatory magnetic field ("Yin-Yang" principle) on hydrogen bonds in order to create water layers around fullerol. Examples of biomedical applications (cancer and Alzheimer's) of this synergetic complex are given. This study shows that the "Yin-Yang" machinery, based on the nanophysics of C molecules and non-covalent hydrogen bonds, is possible. The first attempt has been composed to synthesize nanomaterial for biophysical vibrational nanomedicine.

摘要

为了克服纳米物质在医学上生化应用的负面影响(毒性问题),以富勒烯C的一阶衍生物(富勒醇,FD-C)为例,我们表明当在FD-C周围形成水层时,通过非共价氢键实现其生物物理效应是可能的。SD-C(ζ电位为-43.29 mV)比富勒醇(ζ电位为-25.85 mV)稳定得多,因此富勒醇结构由于不稳定而发生的团聚/破碎会导致毒性作用。当溶液中的富勒醇暴露于实部为[250/-92 mT,H(ω) = H0(ωt)]的振荡磁场时,根据三维平铺形成的彭罗斯过程,在FD-C(富勒醇)周围形成水层,二阶衍生物SD-C(或3HFWC)会自组织形成。然而,当除了SD-C之外还施加外部磁场的虚部[250/-92 mT,H(ω) = H0(ωt)]时,会形成有序水链和水的起泡(“胶束”),作为三阶衍生物(TD-C)。富勒醇(FD-C)通过生化方式与生物结构相互作用,而二阶(SD-C)和三阶(TD-C)衍生物则通过非共价氢键振荡发挥生物物理作用。SD-C和TD-C显著提高了水溶性并降低了毒性。本文解释了以振荡磁场(阴阳原理)对氢键的影响,由FD-C60(富勒醇)作为前体合成SD-C60和TD-C60,以便在富勒醇周围形成水层。给出了这种协同复合物在生物医学应用(癌症和阿尔茨海默病)方面的例子。这项研究表明基于C分子纳米物理学和非共价氢键的“阴阳”机制是可行的。首次尝试合成用于生物物理振动纳米医学的纳米材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3f3/12299826/a2ccc7136a6f/micromachines-16-00770-g001.jpg

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