Koruga Djuro Lj, Matija Lidija R, Stanković Ivana M, Pavlović Vladimir B, Dinić Aleksandra P
NanoLab, Biomedical Engineering, Faculty of Mechanical Engineering, University of Belgrade, 11120 Belgrade, Serbia.
TEM Laboratory, Faculty of Agriculture, University of Belgrade, 11000 Belgrade, Serbia.
Micromachines (Basel). 2025 Jun 30;16(7):770. doi: 10.3390/mi16070770.
To overcome the negative effects of the biochemical application of nano-substances in medicine (toxicity problem), using the example of fullerene C's first derivative (fullerenol, FD-C), we show that their biophysical effect is possible through non-covalent hydrogen bonds when around FD-C water layers are formed. SD-C (Zeta potential is -43.29 mV) is much more stable than fullerol (Zeta potential is -25.85 mV), so agglomeration/fragmentation of the fullerol structure, due to instability, can cause toxic effects. When fullerol in solution was exposed to an oscillatory magnetic field with (real) part [250/-92 mT, H() = (ωt)], water layers around FD-C (fullerenol) are formed according to the Penrose process of 3D tiling formation, and the second derivative, SD-C (or 3HFWC), is self-organized. However, when (imaginary) part [250/-92 mT, H() = (ωt)] of the external magnetic field is applied in addition to SD-C, ordered water chains and bubbling of water ("micelle") are formed as a third derivative (TD-C). Fullerol (FD-C) interacts with biological structures biochemically, while the second (SD-C) and third (TD-C) derivatives act biophysically via non-covalent hydrogen bond oscillation. SD-C and TD-C significantly increased water solubility and reduced toxicity. The paper explains the synthesis of SD-C60 and TD-C60 from FD-C60 (fullerol) as a precursor by the influence of an oscillatory magnetic field ("Yin-Yang" principle) on hydrogen bonds in order to create water layers around fullerol. Examples of biomedical applications (cancer and Alzheimer's) of this synergetic complex are given. This study shows that the "Yin-Yang" machinery, based on the nanophysics of C molecules and non-covalent hydrogen bonds, is possible. The first attempt has been composed to synthesize nanomaterial for biophysical vibrational nanomedicine.
为了克服纳米物质在医学上生化应用的负面影响(毒性问题),以富勒烯C的一阶衍生物(富勒醇,FD-C)为例,我们表明当在FD-C周围形成水层时,通过非共价氢键实现其生物物理效应是可能的。SD-C(ζ电位为-43.29 mV)比富勒醇(ζ电位为-25.85 mV)稳定得多,因此富勒醇结构由于不稳定而发生的团聚/破碎会导致毒性作用。当溶液中的富勒醇暴露于实部为[250/-92 mT,H(ω) = H0(ωt)]的振荡磁场时,根据三维平铺形成的彭罗斯过程,在FD-C(富勒醇)周围形成水层,二阶衍生物SD-C(或3HFWC)会自组织形成。然而,当除了SD-C之外还施加外部磁场的虚部[250/-92 mT,H(ω) = H0(ωt)]时,会形成有序水链和水的起泡(“胶束”),作为三阶衍生物(TD-C)。富勒醇(FD-C)通过生化方式与生物结构相互作用,而二阶(SD-C)和三阶(TD-C)衍生物则通过非共价氢键振荡发挥生物物理作用。SD-C和TD-C显著提高了水溶性并降低了毒性。本文解释了以振荡磁场(阴阳原理)对氢键的影响,由FD-C60(富勒醇)作为前体合成SD-C60和TD-C60,以便在富勒醇周围形成水层。给出了这种协同复合物在生物医学应用(癌症和阿尔茨海默病)方面的例子。这项研究表明基于C分子纳米物理学和非共价氢键的“阴阳”机制是可行的。首次尝试合成用于生物物理振动纳米医学的纳米材料。