Lass J H, Spurney R V, Dutt R M, Andersson H, Kochar H, Rodman H M, Stern R C, Doershuk C F
Am J Ophthalmol. 1985 Dec 15;100(6):783-8. doi: 10.1016/s0002-9394(14)73367-7.
Seven patients with type I diabetes mellitus (Group 1), seven with normoglycemic cystic fibrosis (Group 2), seven with hyperglycemic cystic fibrosis (Group 3), and ten age-matched control subjects underwent corneal fluorophotometry and quantitative specular microscopy. Group 1 had background microangiopathic retinopathy but no evidence of proliferative disease by fluorescein angiography. Significant increases in mean corneal endothelial permeability and mean pump rate occurred in Group 1, indicating a defect in the endothelial barrier function early in type I diabetes mellitus. Similar significant increases in mean corneal endothelial permeability and mean pump rate occurred in both cystic fibrosis groups. The greatest increase was found in Group 3, suggesting a primary defect in the endothelial barrier function in cystic fibrosis, aggravated by the hyperglycemic state. No morphologic abnormalities were noted in Group 1, but both cystic fibrosis groups had smaller mean cell areas than did the control group. There were significant differences in the morphologic and functional correlations between Groups 1 and 3, suggesting different mechanisms for the increased endothelial permeability in these two disorders.
7例1型糖尿病患者（第1组）、7例血糖正常的囊性纤维化患者（第2组）、7例血糖升高的囊性纤维化患者（第3组）以及10例年龄匹配的对照受试者接受了角膜荧光光度测定和定量镜面显微镜检查。第1组有背景性微血管病变性视网膜病变，但荧光素血管造影未显示增殖性疾病的证据。第1组平均角膜内皮通透性和平均泵血速率显著增加，表明1型糖尿病早期内皮屏障功能存在缺陷。两个囊性纤维化组的平均角膜内皮通透性和平均泵血速率也出现类似的显著增加。第3组增加最为明显，提示囊性纤维化存在内皮屏障功能的原发性缺陷，高血糖状态使其加重。第1组未发现形态学异常，但两个囊性纤维化组的平均细胞面积均小于对照组。第1组和第3组在形态学和功能相关性方面存在显著差异，提示这两种疾病中内皮通透性增加的机制不同。
