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秘鲁高地羊驼幼崽（）分离株的基因组特征：对功能多样性和致病性的见解。

Genomic Characterization of Isolates from Alpaca Crias () in the Peruvian Highlands: Insights into Functional Diversity and Pathogenicity.

作者信息

Zapata Celso, Rodríguez Lila, Romero Yolanda, Coila Pedro, Hañari-Quispe Renán Dilton, Oros Oscar, Zanabria Victor, Quilcate Carlos, Rojas Diórman, Cruz Juancarlos, Ortiz Narda, Estrada Richard

机构信息

Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional del Altiplano de Puno, Puno 21001, Peru.

Instituto de Investigación en Bioinformática y Bioestadística, Lima 15024, Peru.

出版信息

Microorganisms. 2025 Jun 30;13(7):1533. doi: 10.3390/microorganisms13071533.

DOI:10.3390/microorganisms13071533
PMID:40732041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12298738/
Abstract

Diarrhea in alpaca crias significantly impacts livestock health in high-altitude regions, with as a common pathogen. This study analyzed 10 isolates from diarrheic and healthy alpacas using whole-genome sequencing to assess genetic diversity, virulence factors, and antibiotic resistance. Predominant sequence types (ST73, ST29), serotypes (O22:H1, O109:H11), and phylogroups (B2, B1, A) were identified. Virulence profiling revealed ExPEC-like and EPEC pathotypes, while resistance genes for β-lactams (), fosfomycin (), and colistin () were prevalent. These findings highlight the need for genomic surveillance and antimicrobial stewardship to manage infections in alpacas and reduce public health risks.

摘要

羊驼幼崽腹泻对高海拔地区的牲畜健康有显著影响， 是一种常见病原体。本研究使用全基因组测序分析了10株来自腹泻和健康羊驼的 分离株，以评估遗传多样性、毒力因子和抗生素耐药性。确定了主要的序列类型（ST73、ST29）、血清型（O22:H1、O109:H11）和系统发育群（B2、B1、A）。毒力分析显示出类肠外致病性大肠杆菌（ExPEC）和肠致病性大肠杆菌（EPEC）致病型，而β-内酰胺类（ ）、磷霉素（ ）和黏菌素（ ）的耐药基因很普遍。这些发现凸显了进行基因组监测和抗菌药物管理以控制羊驼感染并降低公共卫生风险的必要性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/bceaac70b511/microorganisms-13-01533-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/2105ea75b48e/microorganisms-13-01533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/58d64ff574dc/microorganisms-13-01533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/765e812674a6/microorganisms-13-01533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/0dd806e27f4e/microorganisms-13-01533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/e6d21b047aae/microorganisms-13-01533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/156b267859d7/microorganisms-13-01533-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/ea0e965103c2/microorganisms-13-01533-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/8758befd475b/microorganisms-13-01533-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/bceaac70b511/microorganisms-13-01533-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/2105ea75b48e/microorganisms-13-01533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/58d64ff574dc/microorganisms-13-01533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/765e812674a6/microorganisms-13-01533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/0dd806e27f4e/microorganisms-13-01533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/e6d21b047aae/microorganisms-13-01533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/156b267859d7/microorganisms-13-01533-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/ea0e965103c2/microorganisms-13-01533-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/8758befd475b/microorganisms-13-01533-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8248/12298738/bceaac70b511/microorganisms-13-01533-g009.jpg

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J Med Microbiol. 2025 Mar;74(3). doi: 10.1099/jmm.0.001988.
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Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.对印度古吉拉特邦生牛乳中大肠杆菌质粒介导的抗生素抗性基因、毒力因子和可移动遗传元件的基因组学见解。
Sci Rep. 2025 Feb 21;15(1):6320. doi: 10.1038/s41598-025-90761-2.
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Occurrence of virulence genes in multidrug-resistant Escherichia coli isolates from humans, animals, and the environment: One health perspective.
从“同一健康”视角看人类、动物和环境中耐多药大肠杆菌分离株中毒力基因的出现情况
PLoS One. 2025 Jan 24;20(1):e0317874. doi: 10.1371/journal.pone.0317874. eCollection 2025.
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