Wu Shiming, Wang Meishu, Liu Ziyi, Fu Chen
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Microorganisms. 2025 Jul 3;13(7):1570. doi: 10.3390/microorganisms13071570.
The increasing diversity and escalating drug resistance of bacterial pathogens have significantly compromised the efficacy of conventional antimicrobial agents, creating formidable challenges in modern infection control. These developments underscore the critical need for innovative therapeutic strategies to address the persistent global health burden posed by microbial resistance. While metal-based compounds have been extensively studied for their anticancer properties in clinical applications, their potential in antimicrobial contexts remains relatively underexplored. This review systematically elaborates on the structure-activity relationship of metal complexes, with a focus on the unique characteristics of metal drugs that differ from organic small molecules. These drugs can overcome drug resistance through various mechanisms (such as generation of reactive oxygen species and penetration of biological membranes). Understanding these mechanisms provides a crucial basis for guiding ligand design and the development of delivery systems.
细菌病原体的多样性不断增加以及耐药性不断升级，已严重损害了传统抗菌药物的疗效，给现代感染控制带来了巨大挑战。这些进展凸显了迫切需要创新治疗策略来应对微生物耐药性给全球健康带来的持续负担。虽然金属基化合物在临床应用中因其抗癌特性而得到广泛研究，但其在抗菌领域的潜力仍相对未得到充分探索。本综述系统地阐述了金属配合物的构效关系，重点关注与有机小分子不同的金属药物的独特特性。这些药物可通过多种机制（如产生活性氧和穿透生物膜）克服耐药性。了解这些机制为指导配体设计和递送系统的开发提供了关键依据。
