Liu Zhuang, Du Chenxi, Zhou Xin, Wei Gang
School of Basic Medicine, Qingdao University, Qingdao 266071, China.
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.
Polymers (Basel). 2025 Jul 17;17(14):1960. doi: 10.3390/polym17141960.
Developing advanced antimicrobial agents is critically imperative to address antibiotic-resistant infection crises. MXenes have emerged as a potential nanomedicine for antibacterial applications, but they suffer from suboptimal photothermal conversion efficiency and inherent cytotoxicity. Herein, we report the synthesis of MXene (TiC)-based nanohybrids and hybrid membranes through firstly interfacial conjugation of self-assembled β-lactoglobulin nanofibers (β-LGNFs)-inspired copper sulfide nanoparticles (CuS NPs) onto MXene nanosheets, and subsequent vacuum filtration of the created β-LGNF-CuS/MXene nanohybrids. The constructed β-LGNF-CuS/MXene nanohybrids exhibit excellent photothermal conversion performances and satisfactory biocompatibility and minimal cytotoxicity toward mammalian cells, ascribing to the introduction of highly biocompatible β-LGNFs into the hybrid system. In addition, the fabricated β-LGNF-CuS/MXene hybrid membranes demonstrate high efficiency in antibacterial application through the synergistic photothermal and material-related antibacterial effects of both MXene and CuS NPs. Therefore, the ideas and findings shown in this study are useful for inspiring researchers to design and fabricate functional and biocompatible 2D material-based hybrid membranes for antimicrobial applications.
开发先进的抗菌剂对于应对抗生素耐药性感染危机至关重要。MXenes已成为一种潜在的用于抗菌应用的纳米药物，但它们存在光热转换效率欠佳和固有细胞毒性的问题。在此，我们报告了基于MXene（TiC）的纳米杂化物和混合膜的合成方法，首先是将自组装的受β-乳球蛋白纳米纤维（β-LGNFs）启发的硫化铜纳米颗粒（CuS NPs）通过界面共轭作用连接到MXene纳米片上，随后对生成的β-LGNF-CuS/MXene纳米杂化物进行真空过滤。构建的β-LGNF-CuS/MXene纳米杂化物表现出优异的光热转换性能、令人满意的生物相容性以及对哺乳动物细胞的最小细胞毒性，这归因于将高度生物相容的β-LGNFs引入到杂化体系中。此外，制备的β-LGNF-CuS/MXene混合膜通过MXene和CuS NPs的协同光热和与材料相关的抗菌作用，在抗菌应用中显示出高效率。因此，本研究中展示的思路和发现有助于启发研究人员设计和制造用于抗菌应用的功能性和生物相容性二维材料基混合膜。
