Mo Chaodeng, Bajgai Johny, Rahman Md Habibur, Abdul-Nasir Sofian, Ma Hui, Pham Thu Thao, Zhang Haiyang, Cao Buchan, Goh Seong Hoon, Kim Bomi, Kim Hongik, Seol Min Kyeong, Yu Young Geon, Kim Cheol-Su, Lee Kyu-Jae, Lim Seung-Taek
Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
Department of Global Medical Science, Yonsei University Graduate School, Wonju College of Medicine, Wonju 26426, Republic of Korea.
Nutrients. 2025 Jul 9;17(14):2276. doi: 10.3390/nu17142276.
: Modulating ethanol metabolism and attenuating alcohol-induced oxidative stress are promising therapeutic strategies for reducing the severity of hangovers and alleviating their associated physiological burden. : A randomized, double-blind, placebo-controlled, crossover study was conducted to evaluate the effects of the probiotic strain VITA-PB2 on ethanol metabolism, oxidative stress, and hangover-related symptoms in 28 healthy adults. The participants consumed either VITA-PB2 or a placebo before standardized alcohol intake, with a 7-day washout period and subsequent crossover. Primary outcomes included blood ethanol, acetaldehyde levels, and aldehyde dehydrogenase (ALDH) activity. Secondary outcomes measured hangover severity assessed by the Acute Hangover Scale (AHS), liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), oxidative stress indicators reactive oxygen species (ROS) and nitric oxide (NO), and antioxidant responses measured by glutathione peroxidase (GPx), catalase, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity. : VITA-PB2 supplementation led to a sustained reduction in blood ethanol concentrations beginning at 0.5 h post-ingestion compared with the placebo group, indicating more efficient ethanol clearance. Additionally, VITA-PB2 significantly reduced acetaldehyde levels at 1 h post-ingestion ( < 0.05) and increased ALDH activity by 42.15% at 30 min ( < 0.05). It also markedly reduced ROS levels at 1 h ( < 0.05), enhanced glutathione peroxidase (GPx) activity at 2 h ( < 0.01), and significantly improved the subjective hangover symptoms, particularly thirst ( < 0.05). : No adverse effects were reported during the trial, indicating that VITA-PB2 is a safe probiotic. These findings suggest its efficacy in mitigating alcohol-induced oxidative stress and alleviating hangover-related symptoms.
调节乙醇代谢并减轻酒精诱导的氧化应激是减轻宿醉严重程度和缓解其相关生理负担的有前景的治疗策略。一项随机、双盲、安慰剂对照、交叉研究旨在评估益生菌菌株VITA-PB2对28名健康成年人乙醇代谢、氧化应激及宿醉相关症状的影响。参与者在标准酒精摄入前服用VITA-PB2或安慰剂，有7天的洗脱期并随后交叉。主要结局包括血液乙醇、乙醛水平及醛脱氢酶（ALDH）活性。次要结局通过急性宿醉量表（AHS）评估宿醉严重程度，测量包括天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和γ-谷氨酰转移酶（GGT）在内的肝酶，氧化应激指标活性氧（ROS）和一氧化氮（NO），以及通过谷胱甘肽过氧化物酶（GPx）、过氧化氢酶和2,2-二苯基-1-苦基肼（DPPH）清除能力测量的抗氧化反应。与安慰剂组相比，补充VITA-PB2导致摄入后0.5小时开始血液乙醇浓度持续降低，表明乙醇清除更有效。此外，VITA-PB2在摄入后1小时显著降低乙醛水平（<0.05），并在30分钟时使ALDH活性增加42.15%（<0.05）。它还在1小时时显著降低ROS水平（<0.05），在2小时时增强谷胱甘肽过氧化物酶（GPx）活性（<0.01），并显著改善主观宿醉症状，尤其是口渴（<0.05）。试验期间未报告不良反应，表明VITA-PB2是一种安全的益生菌。这些发现表明其在减轻酒精诱导的氧化应激和缓解宿醉相关症状方面的功效。
