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J26 通过维持肠道屏障和调节 MAPK 信号通路缓解酒精性肝炎症。

J26 Alleviating Alcohol-Induced Liver Inflammation by Maintaining the Intestinal Barrier and Regulating MAPK Signaling Pathways.

机构信息

Key Lab of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China.

出版信息

Nutrients. 2022 Dec 30;15(1):190. doi: 10.3390/nu15010190.

DOI:10.3390/nu15010190
PMID:36615846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9824527/
Abstract

Alcoholic liver disease (ALD), as a global health problem, is mainly caused by liver inflammation. Meanwhile, probiotics have been considered as a potential and promising strategy to prevent and alleviate ALD. This study aimed to investigate the ameliorative effect of pre-intaking with J26 ( J26) on alcohol-induced liver inflammation, with emphasis on the underlying mechanism for alleviating ALD. The results indicated that J26 could reduce the abundance of Gram-negative pathogenic bacteria by regulating the gut microbiota in mice with alcoholic liver injury, thereby reducing the lipopolysaccharide (LPS) content in the intestine. In addition, J26 could also maintain the intestinal barrier, prevent LPS from crossing the intestinal barrier to correct disorders of the gut-liver axis and then inhibit the activation of Toll-like receptor 4 (TLR4)-mediated MAPK signaling pathway, reducing liver inflammation and restoring liver functions. In conclusion, pre-intake of J26 could alleviate alcohol-induced liver inflammation, which may be closely related to the role of intestinal microbiota in regulating and maintaining the intestinal barrier and then regulating the MAPK signaling pathway.

摘要

酒精性肝病（ALD）作为一个全球性的健康问题，主要是由肝脏炎症引起的。同时，益生菌被认为是预防和缓解 ALD 的一种有潜力和有前途的策略。本研究旨在探讨预先摄入 J26（J26）对酒精性肝损伤引起的肝炎症的改善作用，重点研究其缓解 ALD 的潜在机制。结果表明，J26 可以通过调节酒精性肝损伤小鼠的肠道微生物群来减少革兰氏阴性病原菌的丰度，从而降低肠道内的脂多糖（LPS）含量。此外，J26 还可以维持肠道屏障，防止 LPS 穿过肠道屏障，纠正肠道-肝脏轴的紊乱，从而抑制 Toll 样受体 4（TLR4）介导的 MAPK 信号通路的激活，减轻肝脏炎症并恢复肝功能。总之，预先摄入 J26 可以缓解酒精引起的肝炎症，这可能与肠道微生物群在调节和维持肠道屏障以及调节 MAPK 信号通路方面的作用密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/5f956722cf5a/nutrients-15-00190-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/867d61bd76a0/nutrients-15-00190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/eb20dd838aec/nutrients-15-00190-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/537e8d6e629a/nutrients-15-00190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/9cf08f056add/nutrients-15-00190-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/1f162eada03c/nutrients-15-00190-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/f774aae2d4df/nutrients-15-00190-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/c48c77431732/nutrients-15-00190-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/2bb5b81cee99/nutrients-15-00190-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/143c58b17c9e/nutrients-15-00190-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/5f956722cf5a/nutrients-15-00190-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/867d61bd76a0/nutrients-15-00190-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/eb20dd838aec/nutrients-15-00190-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/537e8d6e629a/nutrients-15-00190-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/9cf08f056add/nutrients-15-00190-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/1f162eada03c/nutrients-15-00190-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/f774aae2d4df/nutrients-15-00190-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/c48c77431732/nutrients-15-00190-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/2bb5b81cee99/nutrients-15-00190-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/143c58b17c9e/nutrients-15-00190-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b2e/9824527/5f956722cf5a/nutrients-15-00190-g010a.jpg

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[5]
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[8]
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[9]
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本文引用的文献

[1]
polysaccharide prevents alcohol-induced hepatic injury and inflammation by repressing oxidative stress and gut leakiness.

Front Nutr. 2022-8-17

[2]
Intestinal Osteopontin Protects From Alcohol-induced Liver Injury by Preserving the Gut Microbiome and the Intestinal Barrier Function.

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Front Cell Infect Microbiol. 2021

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Food Res Int. 2021-3

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The intestinal microbiota as a therapeutic target in the treatment of NAFLD and ALD.

Biomed Pharmacother. 2021-3

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