Aati Hanan Y, Sarawi Wedad, Attia Hala, Ghazwani Rehab, Aldmaine Lama
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Pharmaceutics. 2025 Jun 26;17(7):830. doi: 10.3390/pharmaceutics17070830.
Medicinal plants such as L., an evergreen shrub from the Asteraceae family, have long been valued for their bioactive compounds and traditional therapeutic uses. In this study, the essential oil of (EOSC) was isolated via hydrodistillation and then comprehensively evaluated for its phytochemical composition and antioxidant, anti-inflammatory, hemolytic, and cytotoxic properties, as well as its in silico bioactivity. In total, 89.5% of the essential oil composition was successfully identified using GC-MS analysis. Hydrocarbon sesquiterpenes constituted the largest fraction (36.0%), followed by oxygenated sesquiterpenes (19.7%). Phytochemical screening revealed high phenolic content (839.50 ± 5.0 mg GAE/g E.O), while the Total Antioxidant Capacity (TAC) assay confirmed its strong antioxidant potential. The oil showed moderate hemolytic activity and significant lipoxygenase inhibition, indicating anti-inflammatory capability. The cytotoxic effects of the EOSC were evaluated using the MTT assay and HepG2 liver cancer cells. A dose-dependent reduction in cell viability was observed, confirming the oil's strong anticancer activity. Molecular docking and ADMET analyses supported the bioactivity of the identified compounds, which showed good drug-likeness and pharmacokinetic properties. These findings demonstrate that EOSC has promising antioxidant and anti-inflammatory properties, suggesting that it could have potential as a safe natural substance for use in drug development and food preservation.
药用植物如菊科的常绿灌木[具体植物名称未给出]，长期以来因其生物活性化合物和传统治疗用途而受到重视。在本研究中，通过水蒸馏法分离出[具体植物名称未给出]的精油（EOSC），然后对其植物化学成分、抗氧化、抗炎、溶血和细胞毒性特性以及计算机模拟生物活性进行了全面评估。使用气相色谱 - 质谱联用（GC - MS）分析成功鉴定了精油成分的89.5%。烃类倍半萜构成最大部分（36.0%），其次是氧化倍半萜（19.7%）。植物化学筛选显示酚类含量高（839.50±5.0毫克没食子酸当量/克精油），而总抗氧化能力（TAC）测定证实了其强大的抗氧化潜力。该油显示出中等程度的溶血活性和显著的脂氧合酶抑制作用，表明具有抗炎能力。使用MTT法和HepG2肝癌细胞评估了EOSC的细胞毒性作用。观察到细胞活力呈剂量依赖性降低，证实了该油具有强大的抗癌活性。分子对接和ADMET分析支持了所鉴定化合物的生物活性，这些化合物显示出良好的类药物性质和药代动力学特性。这些发现表明EOSC具有有前景的抗氧化和抗炎特性，表明它可能作为一种安全的天然物质在药物开发和食品保鲜中具有潜力。
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