Ludasi Krisztina, Sass Anna, Kristó Katalin, Kelemen András, Pintye-Hódi Klára, Sovány Tamás
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u 6., H-6720 Szeged, Hungary.
Department of Technical Informatics, University of Szeged, Tisza Lajos krt. 103., H-6720 Szeged, Hungary.
Pharmaceutics. 2025 Jul 14;17(7):908. doi: 10.3390/pharmaceutics17070908.
Although technology has progressed and novel dosage forms have been developed, tablets are still the most used form of medication. However, the present manufacturing methods of these oral solid dosage forms offer limited capacity for personalized treatment and adaptable dosing. Personalized therapy, with a few exceptions, is not yet a part of routine clinical practice. Drug printing could be a possible approach to increase the use of personalized therapy. The aim of this work was to investigate the role of surface tension and the viscosity of inks in the formation of the printing pattern and to investigate how the porosity of substrate tablets influences the behavior of inks on the surface. Spray-dried mannitol served as a binder and filler, while magnesium stearate functioned as a lubricant in the preparation of substrate tablets. Brilliant Blue dye was a model "drug". The ink formulation was applied to the substrates in three varying quantities. Increasing the viscosity enhanced the drug content, potentially improving printing speed and pattern accuracy. However, it negatively impacted the dosing accuracy due to nozzle clogging and prolonged drying time. Viscosity had a significantly higher impact on the ink behavior than surface tension. Lowering the surface tension improved the dosing accuracy and reduced the drying time but resulted in smaller drop sizes and decreases in pattern accuracy. Reducing the substrate porosity led to longer drying times and diminished pattern accuracy. A target surface tension of around 30 mN/m is suggested for inkjet printing. It is necessary to further investigate the applicability of the technology with solutions of inks with high viscosity and low surface tension, including the API.
尽管技术不断进步且新型剂型不断涌现，但片剂仍是最常用的药物剂型。然而，目前这些口服固体剂型的制造方法在个性化治疗和适应性给药方面的能力有限。除了少数例外情况，个性化治疗尚未成为常规临床实践的一部分。药物打印可能是增加个性化治疗应用的一种可行方法。这项工作的目的是研究表面张力和油墨粘度在打印图案形成中的作用，并研究底物片剂的孔隙率如何影响油墨在其表面的行为。喷雾干燥的甘露醇用作粘合剂和填充剂，而硬脂酸镁在底物片剂制备中用作润滑剂。亮蓝染料作为一种“药物”模型。油墨配方以三种不同的量应用于底物。增加粘度可提高药物含量，可能会提高打印速度和图案精度。然而，由于喷嘴堵塞和干燥时间延长，这对给药精度产生了负面影响。粘度对油墨行为的影响比表面张力显著更高。降低表面张力可提高给药精度并缩短干燥时间，但会导致液滴尺寸变小和图案精度降低。降低底物孔隙率会导致干燥时间延长和图案精度降低。建议喷墨打印的目标表面张力约为30 mN/m。有必要进一步研究该技术对包括活性成分在内的高粘度和低表面张力油墨溶液的适用性。
