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喷墨打印制药。

Inkjet Printing of Pharmaceuticals.

机构信息

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.

Department of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, College Lane, Hatfield, AL10 9AB, UK.

出版信息

Adv Mater. 2024 Mar;36(11):e2309164. doi: 10.1002/adma.202309164. Epub 2023 Dec 12.

Abstract

Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer-by-layer, to create 3D objects or 2D patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever-evolving demands of personalized medicine in the healthcare industry. Although originally developed for nonhealthcare applications, IJP harnesses the potential of pharma-inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma-inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D-printed materials, showcasing their diverse advantages, while exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in an era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient-specific treatment is on the horizon of becoming a tangible reality.

摘要

喷墨打印(IJP)是一种增材制造工艺,它通过选择性地沉积墨水材料,逐层构建 3D 物体或 2D 图案,能够精确控制其结构和组成。这项技术已成为满足医疗保健行业中个性化医疗不断发展需求的一种有吸引力和多功能的方法。尽管最初是为非医疗保健应用开发的,但 IJP 利用了制药墨水的潜力,制药墨水是经过精心配方的含有药物和药物赋形剂的墨水。深入研究制药墨水的配方和成分,揭示了 IJP 实现精确和适应性材料沉积的关键。该综述还将其关注点扩展到包括纸张、薄膜、泡沫、镜片和 3D 打印材料在内的衬底材料,展示了它们多样化的优势,同时探索了广泛的治疗应用。此外,还讨论了硬件和软件改进以及人工智能集成的潜在好处,以提高 IJP 的精度和效率。通过采用这些进步,IJP 具有重塑传统医学制造工艺的巨大潜力,引领医疗精确化的新时代。然而,为了充分利用 IJP 的医疗保健能力,还需要进一步探索和优化。随着研究人员不断推动 IJP 的发展,患者个体化治疗的愿景即将成为现实。

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