Barjaktarević Ana, Coneac Georgeta, Cupara Snežana, Kostić Olivera, Kostić Marina, Olariu Ioana, Vlaia Vicenţiu, Cotan Ana-Maria, Neamu Ştefania, Vlaia Lavinia
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Department II-Pharmaceutical Technology, Formulation and Technology of Drugs Research Center, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.
Pharmaceutics. 2025 Jul 19;17(7):934. doi: 10.3390/pharmaceutics17070934.
Basil essential oil exhibits a wide range of biological activities, including strong antimicrobial and anti-inflammatory effects. Considering the health benefits of basil essential oil (BEO) and the favorable properties of alkyl polyglucoside emulsifiers, novel Montanov™-68-based O/W creams containing BEO were developed and characterized. Additionally, the influence of the emulsifier content on the cream's properties was evaluated. : The physicochemical properties were evaluated by organoleptic examination, physical stability test, and pH and electrical conductivity measurement. The mechanical properties were investigated by rheological, textural, and consistency analyses. In addition, a sensory evaluation protocol was applied. : The cream formulations containing 5% and 7% Montanov™ 68 demonstrated physical stability, with no evidence of phase separation during the observation period or following accelerated aging. The pH values remained within the acceptable range for topical use, and a gradual decrease in electrical conductivity over time was observed. The rheological analyses confirmed the non-Newtonian pseudoplastic behavior with thixotropic flow characteristics. The textural analyses demonstrated that the higher emulsifier content led to increased firmness, consistency, cohesiveness, and index of viscosity. The sensory analysis revealed differences between the alkyl polyglucoside (APG)-based cream formulations only in terms of the elasticity and stickiness. : Although the rheological analyses suggested the better spreadability of the formulation with 5% emulsifier, this was not confirmed by the sensory analysis. However, the APG-based formulations performed significantly better than the synthetic surfactant-based formulation in terms of the absorption, stickiness, and greasiness (during and after application). These results are encouraging for the further evaluation of APG-based creams containing basil essential oil for topical application.
罗勒精油具有广泛的生物活性，包括强大的抗菌和抗炎作用。考虑到罗勒精油（BEO）的健康益处以及烷基多苷乳化剂的优良特性，开发并表征了含BEO的新型基于Montanov™-68的水包油型乳膏。此外，还评估了乳化剂含量对乳膏性质的影响。通过感官检查、物理稳定性测试以及pH和电导率测量来评估其物理化学性质。通过流变学、质地和稠度分析来研究其机械性能。此外，还应用了感官评价方案。含5%和7% Montanov™ 68的乳膏配方表现出物理稳定性，在观察期或加速老化后均未出现相分离迹象。pH值保持在局部应用的可接受范围内，并且随着时间的推移电导率逐渐降低。流变学分析证实其具有非牛顿假塑性行为和触变流动特性。质地分析表明，较高的乳化剂含量导致硬度、稠度、内聚性和粘度指数增加。感官分析显示，仅在弹性和粘性方面，基于烷基多苷（APG）的乳膏配方之间存在差异。尽管流变学分析表明含5%乳化剂的配方具有更好的铺展性，但感官分析并未证实这一点。然而，基于APG的配方在吸收性、粘性和油腻感（涂抹期间和涂抹后）方面明显优于基于合成表面活性剂的配方。这些结果对于进一步评估含罗勒精油的基于APG的外用乳膏具有鼓舞作用。
