Rahayu Dyah U C, Richardson Christopher, Bremner John B, Keller Paul A
School of Science, Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia.
Molecules. 2025 Jul 8;30(14):2899. doi: 10.3390/molecules30142899.
The base-enabled reaction of buta-2,3-dien-1-yl methanesulfonate with the readily available and cheap dye indigo resulted in the convenient one-pot synthesis of benzoindolonaphthyridinedione and benzoazepinopyridoindolediones, with the latter representing two novel heterocyclic scaffolds. Despite the low yields, the allenylic alkylation of indigo significantly contributes to the new chemistry of this compound, providing new mechanistic insights and reactivity boundaries.
丁-2,3-二烯-1-基甲磺酸酯与易于获得且价格低廉的染料靛蓝在碱作用下发生反应，可方便地一锅法合成苯并吲哚并萘啶二酮和苯并氮杂卓吡啶并吲哚二酮，后者代表两种新型杂环骨架。尽管产率较低，但靛蓝的烯丙基烷基化对该化合物的新化学性质有显著贡献，提供了新的机理见解和反应活性边界。
