Allen Michelle, Roerink Frank, Crowley Abigail, Knetter Susan, Morgan Chandra, Wei Huiling, Segers Ruud
Intervet Inc. (d/b/a Merck Animal Health), De Soto, KS 66018, USA.
Intervet International B.V., 5831 AN Boxmeer, The Netherlands.
Vaccines (Basel). 2025 Jun 25;13(7):681. doi: 10.3390/vaccines13070681.
: This study describes multiple trials demonstrating the safety and efficacy of a tri-valent vaccine against diseases caused by Porcine Circovirus Types 2a and 2d (PCV2a, PCV2d), , and . : For each of the PCV2a and PCV2d onset of immunity (OOIs) and duration of immunity (DOI) studies, 25 pigs were vaccinated with a tri-valent vaccine and 25 with placebo. After dual challenge with PCV2a and porcine reproductive and respiratory virus (PRRSV) (OOI) or single challenge with PCV2d (OOI and DOI), respectively, viremia and lymphoid depletion data were collected. For each of the OOI and DOI studies, 35 to 70 pigs were vaccinated with the tri-valent vaccine and 35 to 70 with placebo. After challenge, the lungs were scored for disease. For the OOI study, 40 to 50 pigs were vaccinated with the tri-valent and 40 to 50 with placebo. After challenge, the intestines were scored for disease. All pigs were vaccinated at approximately 3 weeks of age, and all placebo vaccines were product matched. : Vaccinating pigs with a tri-valent vaccine reduced viremia and lymphoid depletion due to PCV2a and PCV2d, reduced lung lesions due to and reduced ileum and colonization scores due to . : The trials reported here demonstrated the safety and efficacy of the first ready-to-use PCV2, , and vaccine for pigs.
本研究描述了多项试验，这些试验证明了一种三价疫苗对由2a型和2d型猪圆环病毒（PCV2a、PCV2d）引起的疾病的安全性和有效性。对于PCV2a和PCV2d的每项免疫起始（OOI）和免疫持续时间（DOI）研究，25头猪接种三价疫苗，25头接种安慰剂。分别在用PCV2a和猪繁殖与呼吸综合征病毒（PRRSV）进行双重攻毒（OOI）或用PCV2d进行单次攻毒（OOI和DOI）后，收集病毒血症和淋巴组织耗竭数据。对于每项OOI和DOI研究，35至70头猪接种三价疫苗，35至70头接种安慰剂。攻毒后，对肺部疾病进行评分。对于OOI研究，40至50头猪接种三价疫苗，40至50头接种安慰剂。攻毒后，对肠道疾病进行评分。所有猪均在约3周龄时接种疫苗，所有安慰剂疫苗均与产品匹配。给猪接种三价疫苗可减少由PCV2a和PCV2d引起的病毒血症和淋巴组织耗竭，减少由[未提及病毒名称]引起的肺部病变，并减少由[未提及病毒名称]引起的回肠病变和定植评分。此处报告的试验证明了首款即用型PCV2[此处原文似乎有缺失内容]疫苗对猪的安全性和有效性。
