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中国宁波慢性肺部呼吸系统疾病老年患者的流感疫苗接种率:免费疫苗接种政策及新冠疫情的影响

Influenza Vaccination Coverage Among Elderly Patients with Chronic Lung Respiratory Disease in Ningbo, China: Impact of Free Vaccination Policies and the COVID-19 Pandemic.

作者信息

Wu Xiaoqing, Chen Jieping, Li Pingping, Yang Tianchi, Ye Lixia

机构信息

School of Public Health, Ningbo University, Ningbo 315211, China.

Ningbo Municipal Center for Disease Prevention and Control, Ningbo 315010, China.

出版信息

Vaccines (Basel). 2025 Jun 29;13(7):705. doi: 10.3390/vaccines13070705.

Abstract

BACKGROUND

Elderly patients with chronic lower respiratory diseases (CLRDs) demonstrate an increased susceptibility to complications arising from influenza. Influenza vaccination remains the most effective strategy against influenza-related diseases among elderly CLRD patients. This study aimed to evaluate the influenza vaccination status of older CLRD patients and the factors affecting influenza vaccination.

METHODS

Using population-based health registries, we analyzed the longitudinal uptake of influenza vaccination among elderly patients with CLRDs in Ningbo from the 2018/19 season to the 2022/23 season. A multivariate logistic regression analysis was performed to identify behavioral determinants influencing influenza vaccination among elderly CLRD patients under Ningbo's post-pandemic free vaccination policy.

RESULTS

An average of 487,309 older patients with CLRDs were included in our analysis for each season. The influenza vaccination rate increased from 3.59% in 2018/19 to 43.32% in the 2022/23 influenza season. There was a significant increase in the proportion of timely influenza vaccinations prior to November 15, rising from 3.01% before the COVID-19 pandemic to 33.90% during the pandemic period. The multivariate logistic regression analysis indicated that both the COVID-19 pandemic and free vaccination policy significantly promoted influenza vaccine uptake. Older CLRD patients with comorbidities such as diabetes, hypertension, or cancer exhibited higher influenza vaccination coverage, whereas those who have experienced acute cardiovascular events showed a lower vaccination rate. Additionally, a prior vaccination history significantly influenced uptake.

CONCLUSIONS

Despite the significant improvement in vaccination rates, coverage among elderly patients with CLRDs remains below the WHO target. Addressing this gap requires integrated interventions that combine expanding the population eligible for free vaccinations, community mobilization efforts, and effective communication regarding cardiovascular safety to mitigate vaccine hesitancy within high-risk groups.

摘要

背景

患有慢性下呼吸道疾病(CLRDs)的老年患者对流感引发的并发症易感性增加。流感疫苗接种仍然是老年CLRD患者预防流感相关疾病的最有效策略。本研究旨在评估老年CLRD患者的流感疫苗接种状况以及影响流感疫苗接种的因素。

方法

利用基于人群的健康登记系统,我们分析了2018/19季节至2022/23季节宁波市老年CLRD患者流感疫苗接种的纵向情况。在宁波疫情后免费接种政策下,进行多因素逻辑回归分析以确定影响老年CLRD患者流感疫苗接种的行为决定因素。

结果

每个季节平均有487309名老年CLRD患者纳入我们的分析。流感疫苗接种率从2018/19季节的3.59%上升至2022/23流感季节的43.32%。11月15日前及时接种流感疫苗的比例显著增加,从新冠疫情前的3.01%升至疫情期间的33.90%。多因素逻辑回归分析表明,新冠疫情和免费接种政策均显著促进了流感疫苗的接种。患有糖尿病、高血压或癌症等合并症的老年CLRD患者流感疫苗接种覆盖率更高,而经历过急性心血管事件的患者接种率较低。此外,既往接种史对疫苗接种有显著影响。

结论

尽管疫苗接种率有显著提高,但老年CLRD患者的接种覆盖率仍低于世界卫生组织的目标。解决这一差距需要综合干预措施,包括扩大免费接种人群、社区动员以及就心血管安全性进行有效沟通,以减少高危人群中的疫苗犹豫情绪。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3d9/12299750/0a8350d1b17e/vaccines-13-00705-g001.jpg

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