Adekile A D
Am J Pediatr Hematol Oncol. 1985 Fall;7(3):261-4. doi: 10.1097/00043426-198507030-00010.
Sickle cell anemia, like other chronic hemolytic states, predisposes to cholelithiasis. However, it seems that other factors, apart from the consequent hyperbilirubinemia, contribute to this predisposition. This concept is supported by the fact that while cholelithiasis is very common among North American sickle cell patients, it is not so common in African patients. It is now believed that African sickle cell patients are protected from developing gallstones because of their low dietary intake of cholesterol and low intake of refined fiber-depleted foods. A review of all the published work on cholelithiasis, in Nigerians in general and sickle cell patients in particular, is presented in this article. A comparison is made with similar studies carried out in North America.
镰状细胞贫血与其他慢性溶血性疾病一样，易患胆结石。然而，除了随之而来的高胆红素血症外，似乎还有其他因素导致了这种易感性。北美镰状细胞患者中胆结石非常常见，而在非洲患者中却并非如此，这一事实支持了这一观点。现在认为，非洲镰状细胞患者由于胆固醇饮食摄入量低和精制纤维缺乏食物摄入量低，从而避免了胆结石的形成。本文综述了所有已发表的关于胆结石的研究，这些研究涉及一般尼日利亚人和尤其是镰状细胞患者。并与在北美进行的类似研究进行了比较。
