Jamalinia Mohamad, Bagheri Lankarani Kamran, Malek-Hosseini Seyed Ali
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Gastroenterol Hepatol Bed Bench. 2025;18(1):115-119. doi: 10.22037/ghfbb.v18i1.3035.
This study aimed to analyze trends in the etiologies of liver transplants at Abu Ali Sina Hospital, Shiraz, Iran, from 2020 to 2024.
Liver transplantation (LT) is a crucial treatment for end-stage liver disease (ESLD). Over time, the etiologies leading to LT have evolved due to changes in disease prevalence, advancements in medical treatments, and public health interventions.
Etiologies of LT were categorized into nine groups: acute liver failure, autoimmune disorders, alcoholic steatohepatitis, liver cancer, vascular, metabolic dysfunction-associated steatohepatitis (MASH), viral hepatitis, metabolic disorders, and others. Trend analysis was performed using Python 3.12 programming language with appropriate libraries.
A total of 1579 patients, 59.9% male with a mean age of 45.12 years (SD: 13.52), were analyzed. Autoimmune disorders emerged as the leading cause of LT, increasing from 32.2% in 2020 to 40.6% in 2024 (p-trend = 0.039). Viral hepatitis cases decreased significantly from 18.1% to 3.0% (p-trend = 0.033). Liver cancer became the third leading cause in 2021, replacing viral hepatitis, while MASH consistently remained the second leading cause.
The significant shifts in LT etiologies underscore the success of public health interventions in reducing the burden of viral-related ESLD. Additionally, the findings highlight the need for ongoing research into the prevention, early diagnosis, and management of autoimmune liver diseases, MASH, and liver cancer. These findings provide critical insights for clinicians and policymakers to enhance liver disease management and allocate resources effectively.
本研究旨在分析2020年至2024年伊朗设拉子阿卜杜勒·阿里·西纳医院肝移植病因的变化趋势。
肝移植（LT）是终末期肝病（ESLD）的关键治疗方法。随着时间的推移，由于疾病患病率的变化、医学治疗的进步以及公共卫生干预措施，导致肝移植的病因也在不断演变。
肝移植的病因分为九组：急性肝衰竭、自身免疫性疾病、酒精性脂肪性肝炎、肝癌、血管性疾病、代谢功能障碍相关脂肪性肝炎（MASH）、病毒性肝炎、代谢紊乱和其他。使用Python 3.12编程语言及适当的库进行趋势分析。
共分析了1579例患者，其中59.9%为男性，平均年龄45.12岁（标准差：13.52）。自身免疫性疾病成为肝移植的主要原因，从2020年的32.2%增至2024年的40.6%（p趋势=0.039）。病毒性肝炎病例从18.1%显著降至3.0%（p趋势=0.033）。肝癌在2021年成为第三大主要原因，取代了病毒性肝炎，而MASH一直是第二大主要原因。
肝移植病因的显著变化凸显了公共卫生干预措施在减轻病毒相关终末期肝病负担方面的成功。此外，研究结果强调需要持续开展关于自身免疫性肝病、MASH和肝癌的预防、早期诊断和管理的研究。这些发现为临床医生和政策制定者加强肝病管理和有效分配资源提供了关键见解。
