基于手性金属有机框架的手性分离技术的发展与应用

Zhu Gege, Ge Li, Li Xinyu, Niu Bing, Chen Qin, Zhong Dan, Sun Xiaodong

Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Medicine, Shanghai University, Shanghai, 200444, China.

Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, 200444, China.

J Pharm Anal. 2025 Jul;15(7):101176. doi: 10.1016/j.jpha.2024.101176. Epub 2024 Dec 28.

Chirality is not only a natural phenomenon but also a bridge between chemistry and life sciences. An effective way to obtain a single enantiomer is through racemates resolution. Recent literature shows that chiral metal-organic frameworks (CMOFs) have many applications in various fields because of their diverse topologies and functionalities. This review outlines the design idea and summarizes the latest synthesis strategies and applications of CMOFs. It highlights key advances and issues in the separation domain. In conclusion, the review provides perspectives on the challenges and prospective advancements of CMOFs materials and CMOFs-based separation technologies.

手性不仅是一种自然现象，也是化学与生命科学之间的一座桥梁。获得单一对映体的有效方法是通过外消旋体拆分。最近的文献表明，手性金属有机框架（CMOFs）由于其多样的拓扑结构和功能，在各个领域都有许多应用。本综述概述了设计理念，总结了CMOFs的最新合成策略和应用。它突出了分离领域的关键进展和问题。总之，本综述提供了关于CMOFs材料和基于CMOFs的分离技术的挑战和前瞻性进展的观点。