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基于肝脏代谢组学和肠道微生物群探究发酵汁对高脂饮食引起的脂质沉积的预防作用及其作用机制

Exploring the Prevention of Lipid Deposition Caused by High-Fat Diet and Its Mechanism of Action of Fermented Juice Based on Liver Metabolomics and Gut Microbiota.

作者信息

Meng Duo, Wang Pengjiao, Zhang Shuo, Chen Zhiyu, Lai Chencen, Yi Xinxin, Huang Xuncai, Yu Haoxiang, Zhang Min, Gao Xiuli

机构信息

State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine and school of pharmaceutical science Guizhou Medical University Guiyang China.

Engineering Research Center of Microbiology and Biochemical Pharmaceutical, Guizhou Provincial Department of Education Guizhou Medical University Guiyang China.

出版信息

Food Sci Nutr. 2025 Jul 28;13(8):e70449. doi: 10.1002/fsn3.70449. eCollection 2025 Aug.

DOI:10.1002/fsn3.70449
PMID:40735404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12301631/
Abstract

Hyperlipidemia has become a prevalent disease in the global epidemic, posing a threat to human health. This study aims to investigate the mechanism by which fermented juice (RRFJ) can prevent lipid deposition induced by a high-fat diet in mice. The results showed that mice in the RRFJ intervention group had significantly reduced body weight as well as lower levels of serum and liver lipid indicators compared to the high-fat diet group. Metagenomic analysis revealed that the RRFJ intervention reversed the decrease in intestinal flora and genes in mice fed a high-fat diet. Liver metabolomics showed that the RRFJ prevented liver dyslipidemia by modulating the biosynthesis of phenylalanine, tyrosine, tryptophan, and phenylalanine metabolism. RRFJ is effective in preventing dyslipidemia through the 'gut-liver axis', which regulates the imbalance of intestinal flora and improves hepatic metabolic profiles. This provides a new intervention strategy for the prevention and treatment of hyperlipidemia.

摘要

高脂血症已成为全球流行的一种常见疾病，对人类健康构成威胁。本研究旨在探讨发酵汁（RRFJ）预防小鼠高脂饮食诱导的脂质沉积的机制。结果表明，与高脂饮食组相比，RRFJ干预组小鼠体重显著降低，血清和肝脏脂质指标水平也较低。宏基因组分析显示，RRFJ干预逆转了高脂饮食小鼠肠道菌群和基因的减少。肝脏代谢组学表明，RRFJ通过调节苯丙氨酸、酪氨酸、色氨酸的生物合成以及苯丙氨酸代谢来预防肝脏血脂异常。RRFJ通过“肠-肝轴”有效预防血脂异常，调节肠道菌群失衡并改善肝脏代谢谱。这为高脂血症的预防和治疗提供了一种新的干预策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/c1af98929c8a/FSN3-13-e70449-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/e5c9785a2d7f/FSN3-13-e70449-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/44a737f18227/FSN3-13-e70449-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/c35ac62020b2/FSN3-13-e70449-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/87510bacd2ec/FSN3-13-e70449-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/8ec13d812df8/FSN3-13-e70449-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/abf5b8f62e75/FSN3-13-e70449-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/2a01bef95107/FSN3-13-e70449-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/c1af98929c8a/FSN3-13-e70449-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/e5c9785a2d7f/FSN3-13-e70449-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/44a737f18227/FSN3-13-e70449-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/c35ac62020b2/FSN3-13-e70449-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/87510bacd2ec/FSN3-13-e70449-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/8ec13d812df8/FSN3-13-e70449-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/abf5b8f62e75/FSN3-13-e70449-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/2a01bef95107/FSN3-13-e70449-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d1c/12301631/c1af98929c8a/FSN3-13-e70449-g007.jpg

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本文引用的文献

[1]
Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications.

Front Nutr. 2025-1-31

[2]
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.

Cell Rep. 2025-2-25

[3]
Analysis of the Protective Effects of -Fermented Juice on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Network Pharmacology and Metabolomics.

Nutrients. 2024-4-30

[4]
Probiotic-fermented edible herbs as functional foods: A review of current status, challenges, and strategies.

Compr Rev Food Sci Food Saf. 2024-3

[5]
Oxymatrine Alleviates High-Fat-High-Fructose-Induced Fatty Liver in Rats: Understanding the Molecular Mechanism Through an Untargeted Metabonomics Study.

Diabetes Metab Syndr Obes. 2023-12-7

[6]
Bergamot polysaccharides relieve DSS-induced ulcerative colitis via regulating the gut microbiota and metabolites.

Int J Biol Macromol. 2023-12-31

[7]
Probiotic Nissle 1917-derived outer membrane vesicles modulate the intestinal microbiome and host gut-liver metabolome in obese and diabetic mice.

Front Microbiol. 2023-8-15

[8]
ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis.

Front Med. 2023-10

[9]
The impact of high-glucose or high-fat diets on the metabolomic profiling of mice.

Front Nutr. 2023-7-10

[10]
Prevention of High-Fat-Diet-Induced Dyslipidemia by LP104 through Mediating Bile Acid Enterohepatic Axis Circulation and Intestinal Flora.

J Agric Food Chem. 2023-5-17

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