Exploring the Prevention of Lipid Deposition Caused by High-Fat Diet and Its Mechanism of Action of Fermented Juice Based on Liver Metabolomics and Gut Microbiota.

Hyperlipidemia has become a prevalent disease in the global epidemic, posing a threat to human health. This study aims to investigate the mechanism by which fermented juice (RRFJ) can prevent lipid deposition induced by a high-fat diet in mice. The results showed that mice in the RRFJ intervention group had significantly reduced body weight as well as lower levels of serum and liver lipid indicators compared to the high-fat diet group. Metagenomic analysis revealed that the RRFJ intervention reversed the decrease in intestinal flora and genes in mice fed a high-fat diet. Liver metabolomics showed that the RRFJ prevented liver dyslipidemia by modulating the biosynthesis of phenylalanine, tyrosine, tryptophan, and phenylalanine metabolism. RRFJ is effective in preventing dyslipidemia through the 'gut-liver axis', which regulates the imbalance of intestinal flora and improves hepatic metabolic profiles. This provides a new intervention strategy for the prevention and treatment of hyperlipidemia.