Amiri Zahra, Taromi Parsa, Alavi Keyvan, Ghahramani Parto, C Cho William, Ramezani Farani Marzieh, Huh Yun Suk
Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd 74877-94149, Iran.
Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.
Nanoscale. 2025 Aug 15;17(32):18477-18504. doi: 10.1039/d5nr00440c.
Quantum dot-doped nanocomposites (QDNCs) represent an innovative breakthrough in diagnostic medicine, enabling ultra-sensitive and accurate detection at disease onset. Utilizing the size-tunable optical properties, high quantum yield, and photostability of quantum dots (QDs), these materials enable the highly sensitive identification of biomarkers at femtomolar concentrations in complex biological environments. The incorporation of QDs into nanocomposites enables them to achieve better diagnostic modes such as targeted delivery, signal amplification, and multifunctionality, with numerous applications in cancer diagnosis, infectious disease diagnosis, and real-time glucometry. Core-shell and hybrid architectures of advanced materials also enhance the stability and biocompatibility of the QDs. Surface functionalization enhancements and green synthesis approaches have alleviated the issues of toxicity and scalability, with the material now being fit for use in the clinical arena. Furthermore, the amalgamation of QDNCs with machine learning is promising for intelligent diagnostic tools capable of real-time analysis and personalized medicine. This review investigates the engineering of QDNCs, their transformative role in healthcare diagnostics, and their potential to revolutionize point-of-care devices. The capability to address significant translational challenges concerning biocompatibility, toxicity, and scalability will enable QD-based technologies to set a new standard for precision diagnostics, ushering in new advancements in global healthcare.
量子点掺杂纳米复合材料（QDNCs）代表了诊断医学领域的一项创新性突破，能够在疾病发作时实现超灵敏且准确的检测。利用量子点（QDs）尺寸可调的光学特性、高量子产率和光稳定性，这些材料能够在复杂生物环境中以飞摩尔浓度高度灵敏地识别生物标志物。将量子点掺入纳米复合材料可使其实现更好的诊断模式，如靶向递送、信号放大和多功能性，在癌症诊断、传染病诊断和实时血糖检测中有众多应用。先进材料的核壳结构和混合结构也增强了量子点的稳定性和生物相容性。表面功能化的改进和绿色合成方法缓解了毒性和可扩展性问题，该材料目前已适合用于临床领域。此外，将QDNCs与机器学习相结合有望开发出能够进行实时分析和个性化医疗的智能诊断工具。本综述研究了QDNCs的工程设计、它们在医疗诊断中的变革性作用以及它们革新即时检测设备的潜力。解决有关生物相容性、毒性和可扩展性等重大转化挑战的能力将使基于量子点的技术为精准诊断树立新标准，引领全球医疗保健领域取得新进展。
