猪中新的非主要组织相容性复合体（MHC）同种抗原系统（SLD）的检测

Detection of a new non-MHC alloantigenic system (SLD) in pigs.

作者信息

Philipsen M, Hruban V, Hradecký J

出版信息

Anim Blood Groups Biochem Genet. 1985;16(3):175-82. doi: 10.1111/j.1365-2052.1985.tb01468.x.

DOI:10.1111/j.1365-2052.1985.tb01468.x

Abstract

A new, non-MHC cell membrane leucocyte alloantigen was detected in pigs by the complement dependent lymphocytotoxic technique. The new leucocyte system was designated SLD. Its product antigen SLD-1 was demonstrated to segregate independently of the SLA, SLB, SLC, A and E antigens. Family studies supplied evidence of a dominant inheritance of SLD-1. Since an allelic antigen could not be demonstrated, only two alleles for this locus are reported, namely SLD1 and SLD-. No evidence of linkage was detected between the above mentioned leucocyte alloantigenic systems and SLD. The antigen was detected on enriched suspensions of T and B cells from peripheral blood, but it was not detected on erythrocytes, granulocytes and thrombocytes.

摘要

通过补体依赖淋巴细胞毒性技术在猪中检测到一种新的、非主要组织相容性复合体（MHC）的细胞膜白细胞同种异体抗原。这个新的白细胞系统被命名为SLD。已证明其产物抗原SLD-1与SLA、SLB、SLC、A和E抗原独立分离。家系研究提供了SLD-1显性遗传的证据。由于未能证明存在等位抗原，因此该位点仅报告了两个等位基因，即SLD1和SLD-。未检测到上述白细胞同种异体抗原系统与SLD之间存在连锁的证据。该抗原在外周血T细胞和B细胞的富集悬液中被检测到，但在红细胞、粒细胞和血小板上未检测到。