猪中血清学定义的（非主要组织相容性复合体）同种异体抗原系统SLB的多态性。

Polymorphism of the SLB serologically defined (non-MHC) alloantigenic system in pigs.

作者信息

Hruban V, Hradecký J, Dvorák P

机构信息

Czechoslovak Academy of Sciences, Department of Genetics, Libĕchov.

出版信息

Anim Genet. 1988;19(3):285-90. doi: 10.1111/j.1365-2052.1988.tb00817.x.

DOI:10.1111/j.1365-2052.1988.tb00817.x

PMID:2462797

Abstract

Six new antigenic specificities (designated SLB-2 to SLB-7) detectable with polyclonal reagents in the complement-dependent lymphocytotoxic test were determined in the SLB alloantigenic system of pigs. The SLB specificities (including the previously described SLB-1) are controlled by 13 alleles. An analysis of a further 121 double backcross matings (with 817 offspring) confirmed that the products of SLB alleles segregated independently of the SLA haplotypes (swine MHC). In addition, in 112 families of the same mating type (with 746 progeny) the map distance of the SLB locus and the highly polymorphic L blood group locus was found to be 7.82 centimorgans in the heterogametic sex and 12.57 centimorgans in the homogametic sex.

摘要

在猪的SLB同种抗原系统中，通过补体依赖淋巴细胞毒性试验，利用多克隆试剂检测到了6种新的抗原特异性（命名为SLB-2至SLB-7）。SLB特异性（包括先前描述的SLB-1）由13个等位基因控制。对另外121次双回交交配（产生817个后代）的分析证实，SLB等位基因的产物独立于SLA单倍型（猪的主要组织相容性复合体）进行分离。此外，在112个相同交配类型的家系（有746个后代）中，发现SLB基因座与高度多态的L血型基因座在异配性别中的图距为7.82厘摩，在同配性别中的图距为12.57厘摩。