Choleva Vivi, Christodoulou Stylianos, Herodotou Fedonas, Quattrocchi Annalisa, Kola Dimitris, Michael Neofytos, Hadjichrysanthou Chryso
Ophthalmology Department, Archbishop Makarios III Hospital, School of Medicine, Nicosia, Cyprus.
University of Cyprus, Nicosia, Cyprus.
J Pediatr Ophthalmol Strabismus. 2025 Jul 30:1-7. doi: 10.3928/01913913-20250619-03.
To assess the incidence and risk factors of retinopathy of prematurity (ROP) in Cyprus and evaluate the validity of United Kingdom-based screening criteria on the population. The findings aimed to optimize ROP screening guidelines for improved neonatal care.
This was a retrospective study of 183 children undergoing ROP screening from January to December 2023 in the only tertiary neonatal intensive care unit in Cyprus.
A total of 33 infants developed ROP (18%) and 11 of these had vision-threatening ROP. Nine infants received treatment and two died prior to treatment. The youngest infant with ROP was born at 24 weeks of gestation and the oldest was born at 32 weeks. Gestational age, birth weight, sepsis, and long oxygen duration have a strong association with ROP, whereas race, multiple births, blood transfusion, and other operations in the neonatal age are not associated with ROP. Every week of increase in gestational age is correlated with reduction in ROP incidence. The severe prematurity group born at 24 to 28 weeks had the highest risk of vision-threatening disease.
Based on the analysis of a cohort of 183 preterm infants who underwent ROP screening over 1 year in the only tertiary-level neonatal intensive care unit in Cyprus, the authors concluded that the 2008 United Kingdom ROP screening criteria are appropriate and valid for this population because no cases of treatment-requiring ROP were missed. The findings indicate that the severity of prematurity is the primary determinant of ROP risk, whereas other independent risk factors appear to have a comparatively lesser impact on the development of ROP. Importantly, this represents the first epidemiological study of ROP in Cyprus, providing a nationally representative assessment of ROP incidence and screening effectiveness.
评估塞浦路斯早产儿视网膜病变（ROP）的发病率及危险因素，并评估基于英国的筛查标准在该人群中的有效性。研究结果旨在优化ROP筛查指南，以改善新生儿护理。
这是一项回顾性研究，对2023年1月至12月在塞浦路斯唯一的三级新生儿重症监护病房接受ROP筛查的183名儿童进行了研究。
共有33名婴儿发生ROP（18%），其中11名患有威胁视力的ROP。9名婴儿接受了治疗，2名在治疗前死亡。患ROP的最年幼婴儿在妊娠24周出生，最年长的在32周出生。胎龄、出生体重、败血症和长时间吸氧与ROP密切相关，而种族、多胞胎、输血和新生儿期的其他手术与ROP无关。胎龄每增加一周，ROP发病率就会降低。出生在24至28周的极早产儿组患威胁视力疾病的风险最高。
基于对塞浦路斯唯一的三级新生儿重症监护病房1年内接受ROP筛查的183名早产儿队列的分析，作者得出结论，2008年英国ROP筛查标准适用于该人群且有效，因为没有漏诊需要治疗的ROP病例。研究结果表明，早产的严重程度是ROP风险的主要决定因素，而其他独立危险因素对ROP发展的影响相对较小。重要的是，这是塞浦路斯首次关于ROP的流行病学研究，提供了具有全国代表性的ROP发病率和筛查有效性评估。
