Zhen Meiyang, Wang Yan, Xu Cheng, Yi Yinhui, Huang Jiali, Li Libo, You Tianyan
School of Agricultural Engineering, Jiangsu University, Key Laboratory of Modern Agricultural Equipment and Technology, Ministry of Education, Zhenjiang, Jiangsu, 212013, China.
School of Agricultural Engineering, Jiangsu University, Key Laboratory of Modern Agricultural Equipment and Technology, Ministry of Education, Zhenjiang, Jiangsu, 212013, China.
Biosens Bioelectron. 2025 Nov 15;288:117833. doi: 10.1016/j.bios.2025.117833. Epub 2025 Jul 29.
The enhancement of electrochemiluminescence (ECL) efficiency in Au nanoclusters (AuNCs) represents a crucial strategy for expanding the application scope of AuNCs in ECL field. However, current research efforts primarily focus on enhancing the ECL efficiency of AuNCs merely from either an emission or excitation perspective. Herein, the present work commenced by considering the roles of the ECL probe and co-reactant, respectively, to develop a dual-enhanced ECL system with the simultaneous enhancement in emission and excitation. Specifically, starting from the perspective of the ECL probe, Ag was doped into AuNCs to prepare Au-Ag bimetallic nanoclusters (AuAgBNCs). On the one hand, the formation of Au-Ag alloy in the core layer exhibited a synergistic effect in enhancing ECL, and on the other hand, the formation of Ag-N bonds in the shell layer restricted the free movement of surface ligands. These two interactions collectively improved the emission efficiency of AuNCs. Concurrently, porous and dendritic Ce-MOFs were introduced as co-reaction accelerator to facilitate the production of triethylamine radicals (TEA) and excited state AuAgBNCs (AuAgBNCs∗), thereby improving the efficiency of the ECL system from the perspective of excitation. Ultimately, based on the dual-enhanced ECL system, a molecularly imprinted polymer-ECL (MIP-ECL) sensor was developed to detect diuron. This study opened new horizons for the creation of metal nanoclusters with superior ECL efficiency from both emission and excitation perspectives.
提高金纳米簇（AuNCs）的电化学发光（ECL）效率是扩大AuNCs在ECL领域应用范围的关键策略。然而，目前的研究主要集中在仅从发射或激发的角度提高AuNCs的ECL效率。在此，本工作分别从ECL探针和共反应剂的作用出发，开发了一种发射和激发同时增强的双增强ECL系统。具体而言，从ECL探针的角度出发，将Ag掺杂到AuNCs中制备Au-Ag双金属纳米簇（AuAgBNCs）。一方面，核心层中Au-Ag合金的形成在增强ECL方面表现出协同效应，另一方面，壳层中Ag-N键的形成限制了表面配体的自由移动。这两种相互作用共同提高了AuNCs的发射效率。同时，引入多孔树枝状Ce-MOFs作为共反应促进剂，以促进三乙胺自由基（TEA）和激发态AuAgBNCs（AuAgBNCs∗）的产生，从而从激发的角度提高ECL系统的效率。最终，基于双增强ECL系统，开发了一种分子印迹聚合物-ECL（MIP-ECL）传感器用于检测敌草隆。本研究从发射和激发两个角度为创建具有优异ECL效率的金属纳米簇开辟了新的视野。
