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From Recovery to Discovery in Excess Post-MI Fibrosis: Targeting ARK5/USP9X for Therapy.

作者信息

Bellini Maria Livia, Sanson Leonardo, Paolocci Nazareno, Dal Maschio Marco

机构信息

Dipartimento di Cardiologia, University La Sapienza, Rome, Italy.

Dipartimento di Scienze Biomediche, Universita' di Padova, Padova, Italy.

出版信息

JACC Basic Transl Sci. 2025 Jul;10(7):101299. doi: 10.1016/j.jacbts.2025.04.013.

DOI:10.1016/j.jacbts.2025.04.013
PMID:40738517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12434200/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c223/12434200/8cdd34a000e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c223/12434200/95c92197dbde/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c223/12434200/8cdd34a000e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c223/12434200/95c92197dbde/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c223/12434200/8cdd34a000e6/gr1.jpg

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本文引用的文献

1
Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.泛素特异性蛋白酶9X调节ARK5的激活并促进纤维化重塑进程。
JACC Basic Transl Sci. 2025 Jul;10(7):101255. doi: 10.1016/j.jacbts.2025.02.014. Epub 2025 Apr 30.
2
Ubiquitin proteasome system in cardiac fibrosis.心脏纤维化中的泛素蛋白酶体系统
J Adv Res. 2024 Dec 7. doi: 10.1016/j.jare.2024.12.006.
3
Untangling the role of RhoA in the heart: protective effect and mechanism.解析 RhoA 在心脏中的作用:保护作用及其机制。
Cell Death Dis. 2024 Aug 9;15(8):579. doi: 10.1038/s41419-024-06928-8.
4
MYC: there is more to it than cancer.MYC:其意义远不止于癌症。
Front Cell Dev Biol. 2024 Mar 6;12:1342872. doi: 10.3389/fcell.2024.1342872. eCollection 2024.
5
Roles of USP9X in cellular functions and tumorigenesis (Review).USP9X在细胞功能和肿瘤发生中的作用(综述)
Oncol Lett. 2023 Oct 10;26(6):506. doi: 10.3892/ol.2023.14093. eCollection 2023 Dec.
6
Cytosolic NUAK1 Enhances ATP Production by Maintaining Proper Glycolysis and Mitochondrial Function in Cancer Cells.胞质中的NUAK1通过维持癌细胞中适当的糖酵解和线粒体功能来增强ATP生成。
Front Oncol. 2020 Jul 10;10:1123. doi: 10.3389/fonc.2020.01123. eCollection 2020.
7
Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation.肌成纤维细胞与纤维化:细胞分化的线粒体与代谢调控
Circ Res. 2020 Jul 17;127(3):427-447. doi: 10.1161/CIRCRESAHA.120.316958. Epub 2020 Jul 16.
8
Fibroblasts in the Infarcted, Remodeling, and Failing Heart.梗死、重塑和衰竭心脏中的成纤维细胞。
JACC Basic Transl Sci. 2019 Jun 24;4(3):449-467. doi: 10.1016/j.jacbts.2019.02.006. eCollection 2019 Jun.
9
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.去调控的 MYC 表达会诱导对 AMPK 相关激酶 5 的依赖性。
Nature. 2012 Mar 28;483(7391):608-12. doi: 10.1038/nature10927.