Acharya Sushree Subhadra, Bhal Subhasmita, Das Biswajit, Kundu Chanakya Nath
Cancer Biology Division, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University (Institute of Eminence), Campus-11, Patia, Bhubaneswar, Odisha, India.
Cancer Biology Division, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University (Institute of Eminence), Campus-11, Patia, Bhubaneswar, Odisha, India; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, United States.
Adv Immunol. 2025;166:1-35. doi: 10.1016/bs.ai.2024.10.006. Epub 2025 Mar 24.
Cancer vaccines have become a promising approach in the fight against cancer, harnessing the remarkable capability of the human immune system to recognize and eliminate cancer cells. These vaccines are specifically engineered to activate the immune response against malignant cells, marking a significant advancement in contemporary research. By capitalizing on the unique ability of the immune system to detect and eliminate cancer cells, these vaccines present promising prospects for both prevention and therapeutic intervention. Recent advancements have provided profound insights into how these vaccines can be tailored to target specific cancer types, enhancing their efficacy and minimizing side effects. This innovative strategy holds the potential to transform cancer care, offering new avenues for durable and effective treatments. This chapter delves into the historical context of cancer vaccine research, discussing various types of cancer vaccines, their mechanisms of action, and the role of adjuvants and delivery systems in enhancing vaccine efficacy. It also covers tumor immunogenicity, how tumor cells evade the immune system, and the combined use of cancer vaccines with other treatment approaches. The chapter aims to elucidate the potential of cancer vaccines to revolutionize cancer treatment and improve patient outcomes.
癌症疫苗已成为对抗癌症的一种有前景的方法,它利用了人体免疫系统识别和消除癌细胞的卓越能力。这些疫苗经过特殊设计,以激活针对恶性细胞的免疫反应,这标志着当代研究的重大进展。通过利用免疫系统检测和消除癌细胞的独特能力,这些疫苗在预防和治疗干预方面都展现出了有前景的前景。最近的进展为如何定制这些疫苗以靶向特定癌症类型提供了深刻见解,提高了它们的疗效并将副作用降至最低。这种创新策略有可能改变癌症治疗方式,为持久有效的治疗提供新途径。本章深入探讨癌症疫苗研究的历史背景,讨论各种类型的癌症疫苗、它们的作用机制以及佐剂和递送系统在提高疫苗疗效中的作用。它还涵盖肿瘤免疫原性、肿瘤细胞如何逃避免疫系统以及癌症疫苗与其他治疗方法的联合使用。本章旨在阐明癌症疫苗彻底改变癌症治疗并改善患者预后的潜力。