Giunta S, Galeazzi L, Turchetti G, Sampaoli G, Groppa G
Antimicrob Agents Chemother. 1985 Sep;28(3):419-20. doi: 10.1128/AAC.28.3.419.
The ionophore antimicrobial agents provide evidence that perturbations of the electrolyte balance of bacterial cells exert a growth-inhibitory activity. Several drugs acting on animal cell membranes have also been shown to be active on bacterial cells. In this paper, we report preliminary susceptibility studies showing that the class of potassium-sparing diuretics acting directly on monovalent cation fluxes on animal cells possesses a selective growth-inhibitory activity on hemolytic streptococci.
离子载体抗菌剂证明，细菌细胞电解质平衡的紊乱会产生生长抑制活性。几种作用于动物细胞膜的药物也已被证明对细菌细胞有活性。在本文中，我们报告了初步的药敏研究，结果表明，直接作用于动物细胞单价阳离子通量的保钾利尿剂类对溶血性链球菌具有选择性生长抑制活性。
