保钾利尿剂阿米洛利和氨苯蝶啶的体外抗链球菌活性。
In vitro antistreptococcal activity of the potassium-sparing diuretics amiloride and triamterene.
作者信息
Giunta S, Galeazzi L, Turchetti G, Sampaoli G, Groppa G
出版信息
Antimicrob Agents Chemother. 1985 Sep;28(3):419-20. doi: 10.1128/AAC.28.3.419.
Abstract
The ionophore antimicrobial agents provide evidence that perturbations of the electrolyte balance of bacterial cells exert a growth-inhibitory activity. Several drugs acting on animal cell membranes have also been shown to be active on bacterial cells. In this paper, we report preliminary susceptibility studies showing that the class of potassium-sparing diuretics acting directly on monovalent cation fluxes on animal cells possesses a selective growth-inhibitory activity on hemolytic streptococci.
摘要
离子载体抗菌剂证明，细菌细胞电解质平衡的紊乱会产生生长抑制活性。几种作用于动物细胞膜的药物也已被证明对细菌细胞有活性。在本文中，我们报告了初步的药敏研究，结果表明，直接作用于动物细胞单价阳离子通量的保钾利尿剂类对溶血性链球菌具有选择性生长抑制活性。
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In vitro antistreptococcal activity of the potassium-sparing diuretics amiloride and triamterene.保钾利尿剂阿米洛利和氨苯蝶啶的体外抗链球菌活性。
Antimicrob Agents Chemother. 1985 Sep;28(3):419-20. doi: 10.1128/AAC.28.3.419.
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本文引用的文献
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In vitro block of murine L 1210 leukemia cell growth by amiloride, an inhibitor of passive Na+ influx.
Life Sci. 1983 Apr 11;32(15):1779-84. doi: 10.1016/0024-3205(83)90842-1.
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Inhibition of nonspecific streptococcal coagglutination reactions.非特异性链球菌凝聚反应的抑制
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Amiloride, a diuretic with in vitro antimicrobial activity.氨氯吡咪，一种具有体外抗菌活性的利尿剂。
Pharmacol Res Commun. 1984 Aug;16(8):821-9. doi: 10.1016/s0031-6989(84)80058-2.
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Amiloride, protein synthesis, and activation of quiescent cells.氨氯吡咪、蛋白质合成与静止细胞的激活。
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Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation.增加钠离子内流是启动大鼠肝细胞增殖所必需的。
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