Giunta S, Pieri C, Groppa G
Pharmacol Res Commun. 1984 Aug;16(8):821-9. doi: 10.1016/s0031-6989(84)80058-2.
The effect of amiloride, an inhibitor of passive sodium influx in animal cells, was investigated on the in vitro bacterial growth. Amiloride blocked the growth of different bacterial strains at concentrations ranging from 25 to 1,300 micrograms/ml. While generally the block was bacteriostatic and bacteria, on amiloride removal, recovered their ability to growth, the drug showed a killing activity on hemolytic streptococci. Gram-positive bacteria revealed a greater susceptibility to amiloride than gram-negative ones. Although an hitherto unknown effect of amiloride cannot be excluded, from the known mechanism of action of amiloride on animal cells it might be suggested that sodium permeability plays a critical role on bacterial multiplication.
研究了氨氯吡脒（一种动物细胞被动钠内流抑制剂）对体外细菌生长的影响。氨氯吡脒在浓度为25至1300微克/毫升范围内可抑制不同细菌菌株的生长。虽然一般来说这种抑制是抑菌性的，且在去除氨氯吡脒后细菌恢复了生长能力，但该药物对溶血性链球菌显示出杀菌活性。革兰氏阳性菌比革兰氏阴性菌对氨氯吡脒更敏感。尽管不能排除氨氯吡脒有迄今未知的作用，但从其对动物细胞已知的作用机制来看，可能提示钠通透性在细菌繁殖中起关键作用。
