• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Comparative effects of gentamicin and tobramycin on excretion of N-acetyl-beta-D-glucosaminidase.庆大霉素和妥布霉素对N-乙酰-β-D-氨基葡萄糖苷酶排泄的比较作用。
Antimicrob Agents Chemother. 1985 Oct;28(4):500-3. doi: 10.1128/AAC.28.4.500.
2
Urinary excretion of N-acetyl-glucosaminidase and beta-2-microglobulin as early markers of gentamicin nephrotoxicity in neonates.
Dev Pharmacol Ther. 1987;10(2):145-52. doi: 10.1159/000457739.
3
[Urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and its isoenzyme B as a marker of the nephrotoxicity of gentamicin: re-test from an animal model].
Pathol Biol (Paris). 1988 Mar;36(3):240-4.
4
The absence of nephrotoxicity and differential nephrotoxicity between tobramycin and gentamicin.
South Med J. 1990 Oct;83(10):1149-52. doi: 10.1097/00007611-199010000-00008.
5
[An early and specific indicator of aminoglycoside nephrotoxicity: isoenzyme B of urinary N-acetyl-beta-D-glucosaminidase (NAG)].
Pathol Biol (Paris). 1986 May;34(5):342-5.
6
[Isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG): new method of evaluating the nephrotoxicity of aminosides. Our experience with dibekacin in geriatrics].
Nephrologie. 1986;7(2):51-5.
7
[Urinary N-acetyl-beta-glucosaminidase as index of renal toxicity (author's transl)].
Toxicol Eur Res. 1981 May;3(3):149-51.
8
Reliability of urinary N-acetyl-beta-D-glucosaminidase as an indicator of renal tubular damage in neonates.尿N-乙酰-β-D-氨基葡萄糖苷酶作为新生儿肾小管损伤指标的可靠性。
Biol Neonate. 1987;52(1):16-21. doi: 10.1159/000242679.
9
The predictive value of urinary N-acetyl-beta-D-glucosaminidase in evaluating aminoglycoside nephrotoxicity.尿N-乙酰-β-D-氨基葡萄糖苷酶在评估氨基糖苷类肾毒性中的预测价值。
Taiwan Yi Xue Hui Za Zhi. 1985 Oct;84(10):1099-107.
10
Clinical evaluation of urinary N-acetyl-beta-D-glucosaminidase activity in patients receiving aminoglycoside and cephalosporin drugs.接受氨基糖苷类和头孢菌素类药物治疗患者尿N-乙酰-β-D-氨基葡萄糖苷酶活性的临床评估
Res Commun Chem Pathol Pharmacol. 1981 Feb;31(2):313-29.

本文引用的文献

1
Studies on glucosaminidase. 4. The fluorimetric assay of N-acetyl-beta-glucosaminidase.氨基葡萄糖苷酶的研究。4. N-乙酰-β-氨基葡萄糖苷酶的荧光测定法。
Biochem J. 1961 Jan;78(1):151-6. doi: 10.1042/bj0780151.
2
The influence of endotoxin-induced pyrexia on the pharmacokinetics of gentamicin in the rabbit.
J Pharmacol Exp Ther. 1981 Feb;216(2):415-8.
3
Clinical nephrotoxicity of tobramycin and gentamicin. A prospective study.妥布霉素和庆大霉素的临床肾毒性。一项前瞻性研究。
JAMA. 1980 Oct 17;244(16):1808-10.
4
Gentamicin dosage requirements: wide interpatient variations in 242 surgery patients with normal renal function.庆大霉素剂量需求：242例肾功能正常的手术患者之间存在广泛的个体差异。
Surgery. 1980 Feb;87(2):164-9.
5
Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients.庆大霉素与妥布霉素的肾毒性比较：201例患者的药代动力学及临床研究
Antimicrob Agents Chemother. 1981 May;19(5):859-66. doi: 10.1128/AAC.19.5.859.
6
Effect of potassium depletion on gentamicin nephrotoxicity.钾缺乏对庆大霉素肾毒性的影响。
J Lab Clin Med. 1981 Aug;98(2):292-301.
7
Increased gentamicin dosage requirements: rapid elimination in 249 gynecology patients.
Am J Obstet Gynecol. 1981 Apr 15;139(8):896-900. doi: 10.1016/0002-9378(81)90954-6.
8
Factors associated with creatinine clearance changes following gentamicin therapy.
Am J Hosp Pharm. 1980 Nov;37(11):1489-95.
9
Comparative toxicity of gentamicin versus tobramycin: a randomized prospective study.庆大霉素与妥布霉素的毒性比较：一项随机前瞻性研究。
J Antimicrob Chemother. 1981 Jan;7(1):81-8. doi: 10.1093/jac/7.1.81.
10
Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin.庆大霉素和妥布霉素肾毒性及耳毒性的双盲比较
N Engl J Med. 1980 May 15;302(20):1106-9. doi: 10.1056/NEJM198005153022002.

庆大霉素和妥布霉素对N-乙酰-β-D-氨基葡萄糖苷酶排泄的比较作用。

Comparative effects of gentamicin and tobramycin on excretion of N-acetyl-beta-D-glucosaminidase.

作者信息

Donta S T, Lembke L A

出版信息

Antimicrob Agents Chemother. 1985 Oct;28(4):500-3. doi: 10.1128/AAC.28.4.500.

DOI:10.1128/AAC.28.4.500
PMID:4073872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180291/
Abstract

Patients receiving gentamicin or tobramycin were studied to determine whether there were differences in the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) between the two groups. The average daily increases in NAG excretion were significantly higher in the group receiving gentamicin. In individual patients, the best correlation with nephrotoxicity was with high initial rates of NAG excretion. If abnormally high initial rates of increase can serve as a prognosticator of nephrotoxicity, it may be possible to alter aminoglycoside therapy and to avoid renal damage.

摘要

对接受庆大霉素或妥布霉素治疗的患者进行了研究，以确定两组之间N-乙酰-β-D-氨基葡萄糖苷酶（NAG）的尿排泄是否存在差异。接受庆大霉素治疗的组中，NAG排泄的平均每日增加量显著更高。在个体患者中，与肾毒性的最佳相关性在于NAG排泄的高初始速率。如果异常高的初始增加速率可作为肾毒性的预后指标，那么有可能改变氨基糖苷类药物的治疗方案并避免肾脏损伤。