Kadam P R, Advani S H, Bhisey A N
Cancer Genet Cytogenet. 1986 Jul;22(3):265-74. doi: 10.1016/0165-4608(86)90163-9.
Sister chromatid exchange frequencies were analyzed in bone marrow cells and in stimulated peripheral blood lymphocytes from 20 patients with Hodgkin's disease. Sister chromatid exchange studies were also carried out in the bone marrow of eight and peripheral blood of 11 normal subjects separately. Among the patients, ten were newly diagnosed and ten patients were survivors who had received therapy 30-64 months prior to studies. The mean sister chromatid exchange frequencies in bone marrow and peripheral blood of untreated patients were 3.93 +/- 0.7/cell and 4.09 +/- 0.91/cell, respectively, which were not significantly different from those of normal subjects (3.22 +/- 0.7/cell and 5.16 +/- 1.3/cell in bone marrow and peripheral blood, respectively). The mean sister chromatid exchange frequencies in bone marrow and peripheral blood in five of the untreated patients 3-4 months after initial therapy and in a treated (30-64 months after therapy) group were close to the sister chromatid exchange values of the untreated group. Analysis of the distribution of exchanges per chromosome or chromosome groups showed a nonrandom distribution of exchanges in chromosomes #1, #2, and #3, and in E-, F-, and G-group chromosomes in the normal controls and in Hodgkin's disease patients.
对20例霍奇金病患者的骨髓细胞和刺激后的外周血淋巴细胞中的姐妹染色单体交换频率进行了分析。还分别对8名正常受试者的骨髓和11名正常受试者的外周血进行了姐妹染色单体交换研究。患者中，10例为新诊断患者，10例为幸存者，他们在研究前30 - 64个月接受过治疗。未经治疗患者的骨髓和外周血中姐妹染色单体交换频率的平均值分别为3.93±0.7/细胞和4.09±0.91/细胞，与正常受试者的频率（骨髓和外周血中分别为3.22±0.7/细胞和5.16±1.3/细胞）无显著差异。5例未经治疗的患者在初始治疗后3 - 4个月以及一个治疗组（治疗后30 - 64个月）的骨髓和外周血中姐妹染色单体交换频率的平均值接近未经治疗组的姐妹染色单体交换值。对每个染色体或染色体组的交换分布分析表明，在正常对照和霍奇金病患者中，1号、2号和3号染色体以及E、F和G组染色体中的交换分布是非随机的。
