Erkoseoglu Ilknur, Duman Mine Kadioglu, Kesim Sabri Murat, Yaris Ersin, Kalyoncu Nuri Ihsan
Faculty of Medicine, Department of Pharmacology, Karadeniz Technical University, Trabzon, Turkiye.
Fundam Clin Pharmacol. 2025 Oct;39(5):e70042. doi: 10.1111/fcp.70042.
Most of the drugs used in the treatment of cardiovascular diseases cause unfavorable effects on erectile functions. In this study, the effect of atorvastatin and gemfibrozil, which have different hypolipidemic mechanisms of action, on the erectile functions observed in mouse corpus cavernosum tissues is evaluated in vitro. Mouse corpus cavernosum tissues are dissected under ketamine and xylazine anesthesia. Vessels were suspended in 30 mL organ baths filled with Krebs solution and aerated with carbogen (95% O, 5% CO) at 37°C. An initial tension of 500 mg was applied to the suspended tissue strips. After a stabilization period of 90 min, the protocols were applied to the tissue. Atorvastatin and gemfibrozil showed no direct contractile or relaxant effect on corpus cavernosum tissues. Both drugs caused a dose-dependent relaxation in tissues precontracted with phenylephrine. Although the relaxant effect of atorvastatin is inhibited 40% by N-nitro-L-arginine methyl ester (L-NAME), these relaxations are totally inhibited by atropine. The relaxations caused by gemfibrozil are inhibited both by L-NAME and atropine. No change was observed in responses of the tissues to acetylcholine, nitroprusside, and electrical field stimulation when incubated with atorvastatin or gemfibrozil. As a conclusion, both drugs showed similar effects on corpus cavernosum tissues. Atorvastatin and gemfibrozil caused these effects via endothelial nitric oxide. When all the results are evaluated, not only did the two drugs show no unfavorable effects, but they may also have some beneficial effects on erectile functions.
大多数用于治疗心血管疾病的药物都会对勃起功能产生不良影响。在本研究中，体外评估了具有不同降血脂作用机制的阿托伐他汀和吉非贝齐对小鼠海绵体组织中观察到的勃起功能的影响。在氯胺酮和赛拉嗪麻醉下解剖小鼠海绵体组织。将血管悬挂在装有 Krebs 溶液的 30 mL 器官浴中，并在 37°C 下用混合气（95% O₂，5% CO₂）通气。对悬挂的组织条施加 500 mg 的初始张力。在 90 分钟的稳定期后，将实验方案应用于组织。阿托伐他汀和吉非贝齐对海绵体组织没有直接的收缩或舒张作用。两种药物都能使预先用去氧肾上腺素收缩的组织产生剂量依赖性舒张。虽然阿托伐他汀的舒张作用被 N-硝基-L-精氨酸甲酯（L-NAME）抑制了 40%，但这些舒张作用完全被阿托品抑制。吉非贝齐引起的舒张作用被 L-NAME 和阿托品均抑制。当与阿托伐他汀或吉非贝齐一起孵育时，组织对乙酰胆碱、硝普钠和电场刺激的反应未观察到变化。总之，两种药物对海绵体组织显示出相似的作用。阿托伐他汀和吉非贝齐通过内皮一氧化氮引起这些作用。综合所有结果来看，这两种药物不仅没有显示出不良影响，而且可能对勃起功能还有一些有益作用。
