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首例干细胞疗法使1型糖尿病患者恢复胰岛素自主分泌:一项医学里程碑。

First-ever stem cell therapy restores insulin independence in type 1 diabetes: A medical milestone.

作者信息

Kumar Dinesh, Tanwar Rajni, Gupta Vrinda

机构信息

School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh 147301, Punjab, India.

出版信息

World J Stem Cells. 2025 Jul 26;17(7):106856. doi: 10.4252/wjsc.v17.i7.106856.

Abstract

Stem cell therapy has emerged as a groundbreaking treatment approach, particularly for type 1 diabetes, where the autoimmune destruction of beta cells necessitates regenerative strategies to restore insulin production. This article focuses on the recent medical milestone in which autologous stem cell therapy led to insulin independence in a type 1 diabetes patient. This article explores the role of stem cell therapy in reversing diabetes, focusing on the recent medical milestone in which stem cell therapy successfully reversed diabetes in a patient. Stem cells, particularly induced pluripotent stem cells, are used to regenerate pancreatic cells that produce insulin, thereby potentially eliminating the need for insulin injections. The study highlights both the promises and challenges of using stem cell therapy for diabetes including concerns about durability of the response, safety and long-term functionality of generated beta cells. Clinical trials and the ethical considerations of using stem cells are also discussed, along with future directions for stem cell-based diabetes therapies.

摘要

干细胞疗法已成为一种开创性的治疗方法,尤其是对于1型糖尿病而言,其中β细胞的自身免疫性破坏需要再生策略来恢复胰岛素分泌。本文重点关注近期的医学里程碑,即自体干细胞疗法使一名1型糖尿病患者实现了胰岛素自主分泌。本文探讨了干细胞疗法在逆转糖尿病方面的作用,重点关注近期干细胞疗法成功使一名患者逆转糖尿病的医学里程碑。干细胞,特别是诱导多能干细胞,被用于再生产生胰岛素的胰腺细胞,从而有可能消除胰岛素注射的需求。该研究强调了使用干细胞疗法治疗糖尿病的前景和挑战,包括对反应持久性、所产生的β细胞的安全性和长期功能的担忧。还讨论了临床试验以及使用干细胞的伦理考量,以及基于干细胞的糖尿病治疗的未来方向。

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