Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Republic of Korea.
Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
Tissue Eng Regen Med. 2024 Apr;21(3):379-394. doi: 10.1007/s13770-024-00627-3. Epub 2024 Mar 19.
The development and use of human embryonic stem cells (hESCs) in regenerative medicine have been revolutionary, offering significant advancements in treating various diseases. These pluripotent cells, derived from early human embryos, are central to modern biomedical research. However, their application is mired in ethical and regulatory complexities related to the use of human embryos.
This review utilized key databases such as ClinicalTrials.gov, EU Clinical Trials Register, PubMed, and Google Scholar to gather recent clinical trials and studies involving hESCs. The focus was on their clinical application in regenerative medicine, emphasizing clinical trials and research directly involving hESCs.
Preclinical studies and clinical trials in various areas like ophthalmology, neurology, endocrinology, and reproductive medicine have demonstrated the versatility of hESCs in regenerative medicine. These studies underscore the potential of hESCs in treating a wide array of conditions. However, the field faces ethical and regulatory challenges, with significant variations in policies and perspectives across different countries.
The potential of hESCs in regenerative medicine is immense, offering new avenues for treating previously incurable diseases. However, navigating the ethical, legal, and regulatory landscapes is crucial for the continued advancement and responsible application of hESC research in the medical field. Considering both scientific potential and ethical implications, a balanced approach is essential for successfully integrating hESCs into clinical practice.
人类胚胎干细胞（hESC）在再生医学中的开发和应用具有革命性意义，为治疗各种疾病带来了重大进展。这些多能细胞源自早期人类胚胎，是现代生物医学研究的核心。然而，由于涉及人类胚胎的使用，其应用面临着复杂的伦理和监管问题。
本综述利用了 ClinicalTrials.gov、EU Clinical Trials Register、PubMed 和 Google Scholar 等关键数据库，收集了涉及 hESC 的近期临床试验和研究。重点关注它们在再生医学中的临床应用，强调了直接涉及 hESC 的临床试验和研究。
在眼科、神经科、内分泌学和生殖医学等各个领域的临床前研究和临床试验表明，hESC 在再生医学中具有多功能性。这些研究强调了 hESC 在治疗广泛疾病条件方面的潜力。然而，该领域面临着伦理和监管挑战，不同国家的政策和观点存在显著差异。
hESC 在再生医学中的潜力巨大，为治疗以前无法治愈的疾病提供了新的途径。然而，为了在医学领域继续推进和负责任地应用 hESC 研究，需要对伦理、法律和监管领域进行探索。在考虑到科学潜力和伦理影响的情况下，需要采取平衡的方法，将 hESC 成功整合到临床实践中。
