Role of protein binding and pharmacokinetics in the lack of correlation between in vitro inhibition of PG-synthetase and in vivo antiinflammatory activity of a homologous series of nonsteroidal antiinflammatory compounds.
作者信息
Ceserani R, Ferrari M, Goldaniga G, Moro E, Buttinoni A
出版信息
Life Sci. 1977 Jul 15;21(2):223-9. doi: 10.1016/0024-3205(77)90305-8.
PMID:407406
Abstract
摘要
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Role of protein binding and pharmacokinetics in the lack of correlation between in vitro inhibition of PG-synthetase and in vivo antiinflammatory activity of a homologous series of nonsteroidal antiinflammatory compounds.蛋白质结合和药代动力学在一系列非甾体抗炎化合物的体外前列腺素合成酶抑制作用与体内抗炎活性缺乏相关性中的作用。
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