Investigation and analysis of 3-year survival and influencing factors in patients with primary gastric cancer.

BACKGROUND

This study explores the 3-year survival outcomes and associated influencing factors in patients with primary gastric cancer treated laparoscopic surgery, providing meaningful guidance for clinical management.

AIM

To evaluate and analyze the 3-year survival outcomes and associated risk factors in patients with primary gastric cancer who underwent laparoscopic surgery.

METHODS

A total of 100 patients with primary gastric cancer who underwent laparoscopic surgery at our hospital between January 2019 and December 2021 were enrolled. These patients were monitored for 3 years, and their survival statuses were recorded. Patients were categorized into survival and non-survival groups based on their outcomes. Data on sex, age, American Society of Anesthesiologists classification, tumor size, depth of invasion, postoperative adjuvant radio-chemotherapy, postoperative carcinoembryonic antigen (CEA) levels, and other clinical parameters were collected and contrasted across groups to identify factors impacting 3-year survival.

RESULTS

After a 3-year follow-up, the survival rate was 73.00% (73 of 100 patients). No significant differences were observed in sex, tumor location, alcohol consumption, smoking status, tumor differentiation, histological type, intraoperative blood loss, or surgical outcomes between patients with varying prognoses ( > 0.05). However, notable disparities were found in age, American Society of Anesthesiologists classification, tumor-node-metastasis (TNM) stage, tumor size, depth of invasion, lymph node metastasis, lymph node dissection, postoperative adjuvant radio-chemotherapy, postoperative CEA levels, surgical duration, extent of gastric resection, and postoperative complications ( < 0.05). Multivariate logistic regression analysis identified age, TNM stage, tumor size, depth of invasion, lymph node metastasis, lymph node dissection, postoperative adjuvant radio-chemotherapy, postoperative CEA levels, surgical duration, extent of gastric resection, and postoperative complications as independent predictors of 3-year survival in patients with primary gastric cancer following laparoscopic surgery ( < 0.05).

CONCLUSION

The 3-year survival outcome for patients undergoing laparoscopic surgery for primary gastric cancer was 73.00%. Key determinants of survival included age, TNM stage, tumor size, depth of invasion, and lymph node metastasis. This analysis of 3-year survival and its influencing factors offers novel perspectives for optimizing clinical interventions in patients with primary gastric cancer treated laparoscopic surgery.