二月桂酸二丁基锡对大鼠脑内神经递质系统及行为的影响。
Influence of di-butyltin dilaurate on brain neurotransmitter systems and behavior in rats.
作者信息
Alam M S, Husain R, Srivastava S P, Seth P K
机构信息
Industrial Toxicology Research Centre, Lucknow, India.
出版信息
Arch Toxicol. 1988 Apr;61(5):373-7. doi: 10.1007/BF00334618.
Exposure to DBTL (20, 40 or 80 mg/kg body weight) caused a decrease in levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) at all treatment levels. Hypothalamus and frontal cortex appeared to be most affected, since levels of all the three amines examined showed changes in these areas. Maximum decrease of DA was found in corpus striatum, NA in pons medulla and of 5-HT in frontal cortex. These animals also showed a decrease in spontaneous locomotor activity and learning at all the doses. The data indicates involvement of hypothalamus and frontal cortical regions of the brain in the neurotoxicity of DBTL.
暴露于DBTL（20、40或80毫克/千克体重）导致所有处理水平下去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）水平降低。下丘脑和额叶皮质似乎受影响最大，因为所检测的所有三种胺类物质在这些区域的水平均出现变化。纹状体中DA下降最多，脑桥延髓中NA下降最多，额叶皮质中5-HT下降最多。这些动物在所有剂量下还表现出自发运动活动和学习能力下降。数据表明大脑的下丘脑和额叶皮质区域参与了DBTL的神经毒性作用。
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