Lu Jing-Wun, Ma Sheng-Hsiang, Ou Wei-Fan, Chen Hsin-Hua, Chen Tai-Li, Liang Chung-Chao
Department of Physical Medicine and Rehabilitation, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Tzu Chi Med J. 2025 Jun 5;37(3):293-298. doi: 10.4103/tcmj.tcmj_154_24. eCollection 2025 Jul-Sep.
OBJECTIVES: Coronavirus disease 2019 (COVID-19) is associated with poor cardiac outcomes and an increased risk of long-term cardiovascular disease. Long-term cardiovascular outcomes among patients with COVID-19 after exercise-based cardiac rehabilitation remain largely unknown. This study aimed to investigate the long-term cardiovascular outcomes of COVID-19 survivors after exercise-based cardiac rehabilitation using real-world data. MATERIALS AND METHODS: We analyzed the data from the US Collaborative Network of the TriNetX Research Database. Adults aged ≥18 years who were diagnosed with COVID-19 between 2020 and 2022 were enrolled in this study. The comparison comprised a cohort of patients receiving exercise-based cardiac rehabilitation and 1:1 propensity score-matched controls. RESULTS: The exercise-based cardiac rehabilitation group was found to have lower risks of developing several long-term cardiovascular outcomes than the controls, such as mortality (hazard ratio [HR] = 0.75 [0.63-0.89]), stroke (HR = 0.81 [0.68-0.94]), myocardial infarction (HR = 0.75 [0.61-0.89]), ischemic cardiomyopathy (HR = 0.86 [0.75-0.99]), heart failure (HR = 0.73 [0.65-0.83]), and nonischemic cardiomyopathy (HR = 0.78 [0.63-0.92]). CONCLUSION: Among COVID-19 survivors, those undergoing cardiac rehabilitation had lower risks of cardiovascular outcomes, including mortality, stroke, myocardial infarction, ischemic cardiomyopathy, heart failure, and nonischemic cardiomyopathy, than those of controls.
目的:2019冠状病毒病(COVID-19)与不良心脏结局及长期心血管疾病风险增加相关。基于运动的心脏康复后COVID-19患者的长期心血管结局在很大程度上仍不清楚。本研究旨在利用真实世界数据调查基于运动的心脏康复后COVID-19幸存者的长期心血管结局。 材料与方法:我们分析了来自TriNetX研究数据库美国协作网络的数据。纳入2020年至2022年间被诊断为COVID-19的≥18岁成年人。比较对象包括一组接受基于运动的心脏康复的患者和1:1倾向评分匹配的对照组。 结果:发现基于运动的心脏康复组发生几种长期心血管结局的风险低于对照组,如死亡率(风险比[HR]=0.75[0.63-0.89])、中风(HR=0.81[0.68-0.94])、心肌梗死(HR=0.75[0.61-0.89])、缺血性心肌病(HR=0.86[0.75-0.99])、心力衰竭(HR=0.73[0.65-0.83])和非缺血性心肌病(HR=0.78[0.63-0.92])。 结论:在COVID-19幸存者中,接受心脏康复的患者发生心血管结局(包括死亡率、中风、心肌梗死、缺血性心肌病、心力衰竭和非缺血性心肌病)的风险低于对照组。
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