Fadly A M, Nazerian K, Nagaraja K, Below G
Avian Dis. 1985 Jul-Sep;29(3):768-77.
A cell-culture-propagated (CC) live-virus hemorrhagic enteritis (HE) vaccine was evaluated for efficacy and safety in two field trials conducted in North Carolina (NC) and Minnesota (MN). At 4 or 5 1/2 weeks of age, 9,839 poults in NC and 15,857 poults in MN were vaccinated with a CC HE vaccine administered via the drinking water. A comparable number of poults were maintained as unvaccinated controls. Vaccinated and unvaccinated poults were compared for seroconversion, response to laboratory challenge with a virulent HE virus at 3 weeks postvaccination, livability, percentage graded A, and average weight at marketing. In both trials, vaccination with the CC HE vaccine resulted in immunity against HE as indicated by seroconversion and by resistance to HE lesions following laboratory challenge with virulent HE virus. Compared with unvaccinated groups, vaccinated groups had a significantly higher percentage of turkeys graded A in the NC trial and in two of three flocks in the MN trial (P less than 0.005). Further, in the NC trial, livability was significantly higher (P less than 0.005) in vaccinated turkeys than in unvaccinated turkeys. These data indicate that the CC HE vaccine is efficacious and safe to use in the field.
在北卡罗来纳州（NC）和明尼苏达州（MN）进行的两项田间试验中，对一种细胞培养繁殖（CC）的活病毒出血性肠炎（HE）疫苗的有效性和安全性进行了评估。在4或5.5周龄时，给NC的9839只火鸡幼雏和MN的15857只火鸡幼雏通过饮水接种CC HE疫苗。保留相当数量的火鸡幼雏作为未接种疫苗的对照。比较接种和未接种疫苗的火鸡幼雏的血清转化情况、接种疫苗3周后对强毒HE病毒实验室攻毒的反应、存活率、A级评分百分比以及上市时的平均体重。在两项试验中，接种CC HE疫苗均产生了针对HE的免疫力，这通过血清转化以及对强毒HE病毒实验室攻毒后的HE病变抵抗力得以体现。与未接种疫苗的组相比，在NC试验以及MN试验的三个鸡群中的两个鸡群中，接种疫苗的组A级火鸡的百分比显著更高（P小于0.005）。此外，在NC试验中，接种疫苗的火鸡的存活率显著高于未接种疫苗的火鸡（P小于0.005）。这些数据表明，CC HE疫苗在田间使用是有效且安全的。
