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使用q2-fmt评估粪便微生物群移植后的微生物群植入程度。

Assessing microbiome engraftment extent following fecal microbiota transplant with q2-fmt.

作者信息

Herman Chloe, Bolyen Evan, Simard Anthony, Gehret Liz, Caporaso J Gregory

机构信息

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.

School of Informatics, Computing and Cyber Systems, Northern Arizona University, Flagstaff, Arizona, United States of America.

出版信息

PLoS Comput Biol. 2025 Jul 31;21(7):e1013299. doi: 10.1371/journal.pcbi.1013299. eCollection 2025 Jul.

Abstract

We present q2-fmt, a QIIME 2 plugin that provides diverse methods for assessing the extent of microbiome engraftment following fecal microbiota transplant. The methods implemented here were informed by a recent literature review on approaches for assessing FMT engraftment, and cover aspects of engraftment including Community Coalescence, Indicator Features, and Resilience. q2-fmt is free for all use, and detailed documentation illustrating worked examples on a real-world data set are provided in the project's documentation.

摘要

我们展示了q2-fmt,这是一个QIIME 2插件,它提供了多种方法来评估粪便微生物群移植后微生物群植入的程度。这里实施的方法是基于最近一篇关于评估FMT植入方法的文献综述,并涵盖了植入的各个方面,包括群落合并、指示特征和恢复力。q2-fmt可供所有人免费使用,并且在项目文档中提供了详细的文档,其中说明了在真实数据集上的实际示例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2278/12327600/3533bffb5433/pcbi.1013299.g001.jpg

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