Bazin R, Ricquier D, Dupuy F, Hoover-Plow J, Lavau M
Biochem J. 1985 Nov 1;231(3):761-4. doi: 10.1042/bj2310761.
The thermogenic capacity of brown adipose tissue has been investigated in I-strain mice to determine whether this tissue could play a role in the lower efficiency of food utilization reported in this strain of mice. (1) As compared with C57BL mice (a control strain), interscapular-brown-adipose-tissue weight and lipid percentage were decreased by 40% and 13% respectively in I-strain mice. (2) Mitochondrial protein content and cytochrome c oxidase activity were similar in the two strains, but the number of mitochondrial GDP-binding sites and uncoupling-protein content were increased by 2-fold in I-strain mice. (3) Fatty acid synthetase and citrate-cleavage enzyme (units/mg of protein) were 3-fold higher in the brown adipose tissue of I-strain mice. These results indicate that I-strain mice possess a very active brown adipose tissue. This enhanced capacity of energy dissipation in brown adipose tissue could contribute to the decreased capacity of I-strain mice to store adipose tissue.
已对I品系小鼠棕色脂肪组织的产热能力进行了研究，以确定该组织是否在该品系小鼠报道的较低食物利用效率中发挥作用。（1）与C57BL小鼠（对照品系）相比，I品系小鼠肩胛间棕色脂肪组织重量和脂质百分比分别降低了40%和13%。（2）两个品系的线粒体蛋白含量和细胞色素c氧化酶活性相似，但I品系小鼠线粒体GDP结合位点数量和解偶联蛋白含量增加了2倍。（3）I品系小鼠棕色脂肪组织中的脂肪酸合成酶和柠檬酸裂解酶（单位/毫克蛋白）高3倍。这些结果表明，I品系小鼠拥有非常活跃的棕色脂肪组织。棕色脂肪组织中这种增强的能量耗散能力可能导致I品系小鼠储存脂肪组织的能力下降。
