Santos Luana Cristina Diniz, Azevedo Lucas Santos, de Siqueira Ezequias Pessoa, Coimbra Mairon César, Alves Stênio Nunes, Castro Ana Hortência Fonsêca, Lima Luciana Alves Rodrigues Dos Santos
Universidade Federal de São João Del-Rei, Divinópolis, Minas Gerais, Brazil.
Centro De Pesquisa René Rachou-Fiocruz/MG, Belo Horizonte, Minas Gerais, Brazil.
Chem Biodivers. 2025 Jul 31:e01126. doi: 10.1002/cbdv.202501126.
Handroanthus impetiginosus is a species known to produce bioactive substances, including compounds with larvicidal activity. This study evaluated the toxicity of hexane extract (HE), fatty acids (FAs), and FA methyl esters (FAMEs) from H. impetiginosus seeds against Culex quinquefasciatus larvae. FAs were obtained by hydrolysis of triglycerides present in HE for 30 and 60 min, and FAMEs were produced by transesterification of FAs for the same time. HE was analyzed by gas chromatography-mass spectrometry (GC-MS). Oleic acid and ethyl oleate were found in abundance in HE. HE, FA30s, and FA60s produced mortality rates above 90% in C. quinquefasciatus larvae; FA60s produced a 100% mortality rate at the highest concentration at which they were tested (250 µg/mL). LD values ranged from 59.70 µg/mL for HE to 1255.41 µg/mL for FAME60s. LD ranged from 194.72 µg/mL for FA30s to 295.56 µg/mL for FA60s. The results indicate that HE and FAs have larvicidal potential.
黄金风铃木是一种已知能产生生物活性物质的物种，包括具有杀幼虫活性的化合物。本研究评估了黄金风铃木种子的己烷提取物（HE）、脂肪酸（FAs）和脂肪酸甲酯（FAMEs）对致倦库蚊幼虫的毒性。通过将HE中存在的甘油三酯水解30分钟和60分钟获得FAs，并在相同时间内通过FAs的酯交换反应生成FAMEs。通过气相色谱-质谱联用（GC-MS）对HE进行分析。在HE中大量发现油酸和油酸乙酯。HE、FA30s和FA60s在致倦库蚊幼虫中产生的死亡率高于90%；FA60s在其测试的最高浓度（250μg/mL）下产生了100%的死亡率。LD值范围从HE的59.70μg/mL到FAME60s的1255.41μg/mL。LD范围从FA30s的194.72μg/mL到FA60s的295.56μg/mL。结果表明，HE和FAs具有杀幼虫潜力。
