[The influence of pipemidic acid on epinephrine and collagen induced platelet aggregation in vitro].

Concentrations of pipemidic acid (Deblaston) similar to maximal levels obtained in the serum of patients with intact renal function after application of therapeutic doses do not influence epinephrine (adrenaline)- or collagen-induced aggregation in vitro. With 20 micrograms/ml pipemidic acid, corresponding 4- to 5-fold maximal serum levels epinephrine-induced aggregation is reduced significantly, while aggregation by collagen is not affected. A significant reduction of epinephrine-induced aggregation as well as of collagen-induced aggregation is brought about only with doses of pipemidic acid as high as 100 micrograms/ml. But these changes still occur within the normal range. Therefore we conclude from our study, that platelet aggregation is not affected in a clinically relevant manner by pipemidic acid.