Reuter H D, Thiele S
Arzneimittelforschung. 1985;35(8):1326-9.
Concentrations of pipemidic acid (Deblaston) similar to maximal levels obtained in the serum of patients with intact renal function after application of therapeutic doses do not influence epinephrine (adrenaline)- or collagen-induced aggregation in vitro. With 20 micrograms/ml pipemidic acid, corresponding 4- to 5-fold maximal serum levels epinephrine-induced aggregation is reduced significantly, while aggregation by collagen is not affected. A significant reduction of epinephrine-induced aggregation as well as of collagen-induced aggregation is brought about only with doses of pipemidic acid as high as 100 micrograms/ml. But these changes still occur within the normal range. Therefore we conclude from our study, that platelet aggregation is not affected in a clinically relevant manner by pipemidic acid.
吡哌酸（消石素）的浓度与肾功能正常患者在应用治疗剂量后血清中获得的最高水平相似，在体外不影响肾上腺素（肾上腺素）或胶原诱导的聚集。当吡哌酸浓度为20微克/毫升时，相当于血清最高水平的4至5倍，肾上腺素诱导的聚集显著减少，而胶原诱导的聚集不受影响。只有当吡哌酸剂量高达100微克/毫升时，肾上腺素诱导的聚集和胶原诱导的聚集才会显著减少。但这些变化仍在正常范围内。因此，我们从研究中得出结论，吡哌酸在临床上不会以相关方式影响血小板聚集。
