Effect of diclofenac sodium (feloran) on platelet aggregation.

The effect of the antiinflammatory non-steroid drug feloran on platelet aggregation in vitro and in vivo was studied. Epinephrine, adenosine diphosphate, and collagen were used as aggregating agents. The platelet aggregation and platelet release reaction were evaluated automatically on two separate curves, using a Lumi aggregometer (Chrono-log Corp.). It was established that feloran in vitro did not influence the aggregation with ADP, but it inhibited the aggregation with collagen and the second wave of the aggregation with epinephrine. The changes in the percent of the maximal aggregation with all aggregating agents, and the reaction time with collagen were demonstrative. The studies carried out in healthy volunteers in vivo exhibited an inhibition of the aggregation both with epinephrine and collagen, the second wave of the aggregation curve being inhibited with epinephrine. The data obtained were interpreted as a result of the inhibition of the platelet release reaction.