Tyutyulkova N, Gorantcheva Y, Lisitchkov T
Methods Find Exp Clin Pharmacol. 1984 Jan;6(1):21-5.
The effect of the antiinflammatory non-steroid drug feloran on platelet aggregation in vitro and in vivo was studied. Epinephrine, adenosine diphosphate, and collagen were used as aggregating agents. The platelet aggregation and platelet release reaction were evaluated automatically on two separate curves, using a Lumi aggregometer (Chrono-log Corp.). It was established that feloran in vitro did not influence the aggregation with ADP, but it inhibited the aggregation with collagen and the second wave of the aggregation with epinephrine. The changes in the percent of the maximal aggregation with all aggregating agents, and the reaction time with collagen were demonstrative. The studies carried out in healthy volunteers in vivo exhibited an inhibition of the aggregation both with epinephrine and collagen, the second wave of the aggregation curve being inhibited with epinephrine. The data obtained were interpreted as a result of the inhibition of the platelet release reaction.
研究了抗炎非甾体药物非洛兰对体外和体内血小板聚集的影响。使用肾上腺素、二磷酸腺苷和胶原作为聚集剂。使用Lumi聚集仪（Chrono-log公司）在两条单独的曲线上自动评估血小板聚集和血小板释放反应。结果表明，非洛兰在体外不影响ADP诱导的聚集，但能抑制胶原诱导的聚集以及肾上腺素诱导聚集的第二波。所有聚集剂诱导的最大聚集百分比变化以及与胶原的反应时间具有指示性。在健康志愿者体内进行的研究表明，非洛兰对肾上腺素和胶原诱导的聚集均有抑制作用，肾上腺素诱导聚集曲线的第二波受到抑制。所获得的数据被解释为血小板释放反应受到抑制的结果。
