Müller P, Dammann H G, Simon B
Arzneimittelforschung. 1985;35(8):1331-3.
In healthy volunteers the effect of proglumetacin (Protaxon) on different functions of gastric and duodenal mucosa has been compared with that of indometacin in double-blind cross-over design. Pretreatment with 150 mg proglumetacin t.i.d. and 50 mg indometacin t.i.d. did not affect both human acid secretion as well as gastric microbleeding rate. Whereas treatment with 50 mg indometacin t.i.d. over 6 days induced gastric mucosal injury by about 2.4 +/- 0.25--as evaluated endoscopically--significantly lesser changes were seen following 150 mg proglumetacin t.i.d. (1.13 +/- 0.13) (p less than 0.001).
在健康志愿者中，采用双盲交叉设计，比较了丙谷美辛（Protaxon）与吲哚美辛对胃和十二指肠黏膜不同功能的影响。每日三次服用150毫克丙谷美辛和每日三次服用50毫克吲哚美辛进行预处理，对人体胃酸分泌以及胃微出血率均无影响。然而，每日三次服用50毫克吲哚美辛，持续6天，通过内镜评估，可导致胃黏膜损伤约2.4±0.25；而每日三次服用150毫克丙谷美辛后，观察到的变化明显较小（1.13±0.13）（p<0.001）。
