Rubba P, Postiglione A, Scarpato N, Iannuzzi A, Mancini M
Atherosclerosis. 1985 Aug;56(2):237-42. doi: 10.1016/0021-9150(85)90022-x.
By using a non-invasive methodology of vascular diagnosis, ECG-triggered strain-gauge plethysmography, 5 patients with familial hypercholesterolemia (FH) (3 homozygous, 2 heterozygous) were evaluated before and during the 1st and 2nd week after plasma exchange (PE). In order to obtain data on the responsiveness to vasodilating stimuli in FH patients undergoing PE, reactive hyperemia test and peak flow determination were also performed. Resting arterial flow over the calf was found to be significantly enhanced after PE. Reactive hyperemia test demonstrated persistent improvement of peak flow following exchange. This study demonstrates useful hemodynamic effects of PE in patients with FH.
通过使用一种无创性血管诊断方法，即心电图触发应变片体积描记法，对5例家族性高胆固醇血症（FH）患者（3例纯合子，2例杂合子）在血浆置换（PE）前以及第1周和第2周期间进行了评估。为了获取接受PE的FH患者对血管舒张刺激的反应性数据，还进行了反应性充血试验和峰值血流测定。发现小腿部的静息动脉血流在PE后显著增强。反应性充血试验表明置换后峰值血流持续改善。本研究证明了PE对FH患者有有益的血液动力学效应。
